Contents
08 March 2017
Vol 9, Issue 380
Vol 9, Issue 380
Research Articles
- A member of the gut mycobiota modulates host purine metabolism exacerbating colitis in mice
Saccharomyces cerevisiae induces purine metabolism in mouse intestinal epithelia, resulting in an exacerbation of colitis.
- An oral microjet vaccination system elicits antibody production in rabbits
A needle-free device delivers a liquid jet of vaccine that penetrates the buccal mucosa and elicits antibody production in rabbits.
- Antagonism of EGFR and Notch limits resistance to EGFR inhibitors and radiation by decreasing tumor-initiating cell frequency
An anti-EGFR/Notch antibody limits acquired resistance to EGFR inhibitors and radiation by reducing tumor-initiating cell frequency.
- A semisynthetic Streptococcus pneumoniae serotype 8 glycoconjugate vaccine
Automated glycan assembly enabled antibody reverse engineering to develop a semisynthetic carbohydrate–based vaccine against the highly virulent Streptococcus pneumoniae serotype 8.
Editors' Choice
- Kill or be killed: The epic battle between Zika virus and cells revealed
Protein-gene interactome map reveals how Zika virus overrides molecular machinery in human neurospheres.
- The importance of staying small
Long-lived and cancer-resistant adult dwarf rodents have enhanced DNA repair capacity due to decreased GH/IGF-1 signaling during peripubertal development.
- From MDS/AML to iPSC and back again
iPSC lines derived from MDS and AML patient samples can map clonal evolution, disease progression and regression, and identify disease stage–specific medication effects.
- The brain’s matchmakers
Pericytes match capillary blood flow to local neural activity, thus ensuring proper oxygenation of the brain.
About The Cover
ONLINE COVER Fungi Take Center Stage. A strain of yeast (yellow) that is part of the gut mycobiota exacerbates inflammatory bowel disease in a mouse model (Chiaro et al.). Yeast are shown in close proximity to the mouse gut epithelium (villi are represented by peaks and valleys) where they induce purine metabolism leading to production of uric acid (blue crystals), increased gut permeability, and consequently a worsening of colitis. Treating mice with the drug allopurinol, which reduces uric acid production, helps to ameliorate colitis in these animals. [CREDIT: ALEXANDER TOKAREV/ELLA MARU STUDIO]
