08 March 2017
Vol 9, Issue 380

About The Cover

Cover image expansion

ONLINE COVER Fungi Take Center Stage. A strain of yeast (yellow) that is part of the gut mycobiota exacerbates inflammatory bowel disease in a mouse model (Chiaro et al.). Yeast are shown in close proximity to the mouse gut epithelium (villi are represented by peaks and valleys) where they induce purine metabolism leading to production of uric acid (blue crystals), increased gut permeability, and consequently a worsening of colitis. Treating mice with the drug allopurinol, which reduces uric acid production, helps to ameliorate colitis in these animals. [CREDIT: ALEXANDER TOKAREV/ELLA MARU STUDIO]