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Research ArticleCancer
Integrated molecular analysis of tumor biopsies on sequential CTLA-4 and PD-1 blockade reveals markers of response and resistance
- View ORCID ProfileWhijae Roh1,2,*,
- View ORCID ProfilePei-Ling Chen1,3,*,
- View ORCID ProfileAlexandre Reuben4,*,
- View ORCID ProfileChristine N. Spencer1,
- Peter A. Prieto4,
- View ORCID ProfileJohn P. Miller5,
- View ORCID ProfileVancheswaran Gopalakrishnan4,
- Feng Wang1,
- View ORCID ProfileZachary A. Cooper1,4,
- Sangeetha M. Reddy6,
- View ORCID ProfileCurtis Gumbs1,
- View ORCID ProfileLatasha Little1,
- Qing Chang1,
- View ORCID ProfileWei-Shen Chen1,3,
- Khalida Wani7,
- Mariana Petaccia De Macedo7,8,
- View ORCID ProfileEveline Chen7,
- View ORCID ProfileJacob L. Austin-Breneman4,
- Hong Jiang4,
- View ORCID ProfileJason Roszik1,9,
- View ORCID ProfileMichael T. Tetzlaff3,
- Michael A. Davies9,
- View ORCID ProfileJeffrey E. Gershenwald4,
- View ORCID ProfileHussein Tawbi9,
- View ORCID ProfileAlexander J. Lazar4,7,
- View ORCID ProfilePatrick Hwu9,
- View ORCID ProfileWen-Jen Hwu9,
- View ORCID ProfileAdi Diab9,
- View ORCID ProfileIsabella C. Glitza9,
- Sapna P. Patel9,
- Scott E. Woodman9,
- Rodabe N. Amaria9,
- View ORCID ProfileVictor G. Prieto3,
- Jianhua Hu10,
- Padmanee Sharma11,12,
- James P. Allison11,
- Lynda Chin13,
- Jianhua Zhang14,
- View ORCID ProfileJennifer A. Wargo1,4,†,‡ and
- View ORCID ProfileP. Andrew Futreal1,†,‡
- 1Department of Genomic Medicine, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
- 2Cancer Biology Graduate Program, The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences at Houston, Houston, TX 77030, USA.
- 3Department of Pathology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
- 4Department of Surgical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
- 5Oncology Research for Biologics and Immunotherapy Translation, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
- 6Division of Cancer Medicine, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
- 7Department of Translational Molecular Pathology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
- 8Pathology Department, A.C.Camargo Cancer Center, São Paulo, SP-01509-010, Brazil.
- 9Department of Melanoma Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
- 10Department of Biostatistics, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
- 11Department of Immunology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
- 12Department of Genitourinary Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
- 13University of Texas System, Austin, TX 78701, USA.
- 14Applied Cancer Science Institute, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
- ↵‡Corresponding author. Email: afutreal{at}mdanderson.org (P.A.F.); jwargo{at}mdanderson.org (J.A.W.)
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Science Translational Medicine 01 Mar 2017:
Vol. 9, Issue 379, eaah3560
DOI: 10.1126/scitranslmed.aah3560
Vol. 9, Issue 379, eaah3560
DOI: 10.1126/scitranslmed.aah3560
Whijae Roh
1Department of Genomic Medicine, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
2Cancer Biology Graduate Program, The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences at Houston, Houston, TX 77030, USA.
Pei-Ling Chen
1Department of Genomic Medicine, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
3Department of Pathology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Alexandre Reuben
4Department of Surgical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Christine N. Spencer
1Department of Genomic Medicine, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Peter A. Prieto
4Department of Surgical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
John P. Miller
5Oncology Research for Biologics and Immunotherapy Translation, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Vancheswaran Gopalakrishnan
4Department of Surgical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Feng Wang
1Department of Genomic Medicine, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Zachary A. Cooper
1Department of Genomic Medicine, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
4Department of Surgical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Sangeetha M. Reddy
6Division of Cancer Medicine, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Curtis Gumbs
1Department of Genomic Medicine, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Latasha Little
1Department of Genomic Medicine, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Qing Chang
1Department of Genomic Medicine, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Wei-Shen Chen
1Department of Genomic Medicine, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
3Department of Pathology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Khalida Wani
7Department of Translational Molecular Pathology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Mariana Petaccia De Macedo
7Department of Translational Molecular Pathology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
8Pathology Department, A.C.Camargo Cancer Center, São Paulo, SP-01509-010, Brazil.
Eveline Chen
7Department of Translational Molecular Pathology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Jacob L. Austin-Breneman
4Department of Surgical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Hong Jiang
4Department of Surgical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Jason Roszik
1Department of Genomic Medicine, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
9Department of Melanoma Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Michael T. Tetzlaff
3Department of Pathology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Michael A. Davies
9Department of Melanoma Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Jeffrey E. Gershenwald
4Department of Surgical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Hussein Tawbi
9Department of Melanoma Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Alexander J. Lazar
4Department of Surgical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
7Department of Translational Molecular Pathology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Patrick Hwu
9Department of Melanoma Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Wen-Jen Hwu
9Department of Melanoma Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Adi Diab
9Department of Melanoma Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Isabella C. Glitza
9Department of Melanoma Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Sapna P. Patel
9Department of Melanoma Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Scott E. Woodman
9Department of Melanoma Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Rodabe N. Amaria
9Department of Melanoma Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Victor G. Prieto
3Department of Pathology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Jianhua Hu
10Department of Biostatistics, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Padmanee Sharma
11Department of Immunology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
12Department of Genitourinary Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
James P. Allison
11Department of Immunology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Lynda Chin
13University of Texas System, Austin, TX 78701, USA.
Jianhua Zhang
14Applied Cancer Science Institute, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Jennifer A. Wargo
1Department of Genomic Medicine, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
4Department of Surgical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
P. Andrew Futreal
1Department of Genomic Medicine, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
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