Research ArticleCancer

Integrated molecular analysis of tumor biopsies on sequential CTLA-4 and PD-1 blockade reveals markers of response and resistance

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Science Translational Medicine  01 Mar 2017:
Vol. 9, Issue 379, eaah3560
DOI: 10.1126/scitranslmed.aah3560

Article Information

vol. 9 no. 379

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History: 
  • Received for publication August 3, 2016
  • Resubmitted November 17, 2016
  • Accepted for publication February 4, 2017
  • .

Author Information

  1. Whijae Roh1,2,*,
  2. Pei-Ling Chen1,3,*,
  3. Alexandre Reuben4,*,
  4. Christine N. Spencer1,
  5. Peter A. Prieto4,
  6. John P. Miller5,
  7. Vancheswaran Gopalakrishnan4,
  8. Feng Wang1,
  9. Zachary A. Cooper1,4,
  10. Sangeetha M. Reddy6,
  11. Curtis Gumbs1,
  12. Latasha Little1,
  13. Qing Chang1,
  14. Wei-Shen Chen1,3,
  15. Khalida Wani7,
  16. Mariana Petaccia De Macedo7,8,
  17. Eveline Chen7,
  18. Jacob L. Austin-Breneman4,
  19. Hong Jiang4,
  20. Jason Roszik1,9,
  21. Michael T. Tetzlaff3,
  22. Michael A. Davies9,
  23. Jeffrey E. Gershenwald4,
  24. Hussein Tawbi9,
  25. Alexander J. Lazar4,7,
  26. Patrick Hwu9,
  27. Wen-Jen Hwu9,
  28. Adi Diab9,
  29. Isabella C. Glitza9,
  30. Sapna P. Patel9,
  31. Scott E. Woodman9,
  32. Rodabe N. Amaria9,
  33. Victor G. Prieto3,
  34. Jianhua Hu10,
  35. Padmanee Sharma11,12,
  36. James P. Allison11,
  37. Lynda Chin13,
  38. Jianhua Zhang14,
  39. Jennifer A. Wargo1,4,, and
  40. P. Andrew Futreal1,,
  1. 1Department of Genomic Medicine, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
  2. 2Cancer Biology Graduate Program, The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences at Houston, Houston, TX 77030, USA.
  3. 3Department of Pathology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
  4. 4Department of Surgical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
  5. 5Oncology Research for Biologics and Immunotherapy Translation, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
  6. 6Division of Cancer Medicine, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
  7. 7Department of Translational Molecular Pathology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
  8. 8Pathology Department, A.C.Camargo Cancer Center, São Paulo, SP-01509-010, Brazil.
  9. 9Department of Melanoma Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
  10. 10Department of Biostatistics, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
  11. 11Department of Immunology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
  12. 12Department of Genitourinary Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
  13. 13University of Texas System, Austin, TX 78701, USA.
  14. 14Applied Cancer Science Institute, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
  1. Corresponding author. Email: afutreal{at}mdanderson.org (P.A.F.); jwargo{at}mdanderson.org (J.A.W.)
    • * These authors contributed equally to this work.

    • Co-senior authors.

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