Transplantation of fecal microbiota from patients with irritable bowel syndrome alters gut function and behavior in recipient mice

Giada De Palma; Michael D. J. Lynch; Jun Lu; Vi T. Dang; Yikang Deng; Jennifer Jury; Genevieve Umeh; Pedro M. Miranda; Marc Pigrau Pastor; Sacha Sidani; Maria Ines Pinto-Sanchez; Vivek Philip; Peter G. McLean; Moreno-Gabriel Hagelsieb; Michael G. Surette; Gabriela E. Bergonzelli; Elena F. Verdu; Philip Britz-McKibbin; Josh D. Neufeld; Stephen M. Collins; Premysl Bercik

doi:10.1126/scitranslmed.aaf6397

Research ArticleGUT MICROBIOTA

Transplantation of fecal microbiota from patients with irritable bowel syndrome alters gut function and behavior in recipient mice

Giada De Palma¹,
Michael D. J. Lynch²,
Jun Lu¹,
Vi T. Dang³,
Yikang Deng¹,
Jennifer Jury¹,
Genevieve Umeh¹,
Pedro M. Miranda¹,
Marc Pigrau Pastor¹,
Sacha Sidani¹,
Maria Ines Pinto-Sanchez¹,
Vivek Philip¹,
Peter G. McLean⁴,
Moreno-Gabriel Hagelsieb⁵,
Michael G. Surette¹,
Gabriela E. Bergonzelli⁴,
Elena F. Verdu¹,
Philip Britz-McKibbin³,
Josh D. Neufeld²,
Stephen M. Collins¹ and
Premysl Bercik¹,*

¹Farncombe Family Digestive Health Research Institute, Department of Medicine, McMaster University, Hamilton, Ontario, Canada.
²Department of Biology, University of Waterloo, Waterloo, Ontario, Canada.
³Department of Chemistry and Chemical Biology, McMaster University, Hamilton, Ontario, Canada.
⁴Nestlé Research Center, Lausanne, Switzerland.
⁵Department of Biology, Wilfrid Laurier University, Waterloo, Ontario, Canada.

↵*Corresponding author. Email: bercikp{at}mcmaster.ca

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Science Translational Medicine 01 Mar 2017:
Vol. 9, Issue 379, eaaf6397
DOI: 10.1126/scitranslmed.aaf6397

Giada De Palma

Farncombe Family Digestive Health Research Institute, Department of Medicine, McMaster University, Hamilton, Ontario, Canada.

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Michael D. J. Lynch

Department of Biology, University of Waterloo, Waterloo, Ontario, Canada.

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Jun Lu

Farncombe Family Digestive Health Research Institute, Department of Medicine, McMaster University, Hamilton, Ontario, Canada.

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Vi T. Dang

Department of Chemistry and Chemical Biology, McMaster University, Hamilton, Ontario, Canada.

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Yikang Deng

Farncombe Family Digestive Health Research Institute, Department of Medicine, McMaster University, Hamilton, Ontario, Canada.

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Jennifer Jury

Farncombe Family Digestive Health Research Institute, Department of Medicine, McMaster University, Hamilton, Ontario, Canada.

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Genevieve Umeh

Farncombe Family Digestive Health Research Institute, Department of Medicine, McMaster University, Hamilton, Ontario, Canada.

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Pedro M. Miranda

Farncombe Family Digestive Health Research Institute, Department of Medicine, McMaster University, Hamilton, Ontario, Canada.

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Marc Pigrau Pastor

Farncombe Family Digestive Health Research Institute, Department of Medicine, McMaster University, Hamilton, Ontario, Canada.

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Sacha Sidani

Farncombe Family Digestive Health Research Institute, Department of Medicine, McMaster University, Hamilton, Ontario, Canada.

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Maria Ines Pinto-Sanchez

Farncombe Family Digestive Health Research Institute, Department of Medicine, McMaster University, Hamilton, Ontario, Canada.

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Vivek Philip

Farncombe Family Digestive Health Research Institute, Department of Medicine, McMaster University, Hamilton, Ontario, Canada.

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Peter G. McLean

Nestlé Research Center, Lausanne, Switzerland.

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Moreno-Gabriel Hagelsieb

Department of Biology, Wilfrid Laurier University, Waterloo, Ontario, Canada.

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Michael G. Surette

Farncombe Family Digestive Health Research Institute, Department of Medicine, McMaster University, Hamilton, Ontario, Canada.

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Gabriela E. Bergonzelli

Nestlé Research Center, Lausanne, Switzerland.

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Elena F. Verdu

Farncombe Family Digestive Health Research Institute, Department of Medicine, McMaster University, Hamilton, Ontario, Canada.

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Philip Britz-McKibbin

Department of Chemistry and Chemical Biology, McMaster University, Hamilton, Ontario, Canada.

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Josh D. Neufeld

Department of Biology, University of Waterloo, Waterloo, Ontario, Canada.

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Stephen M. Collins

Farncombe Family Digestive Health Research Institute, Department of Medicine, McMaster University, Hamilton, Ontario, Canada.

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Premysl Bercik

Farncombe Family Digestive Health Research Institute, Department of Medicine, McMaster University, Hamilton, Ontario, Canada.

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For correspondence: bercikp@mcmaster.ca

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Transplantation of fecal microbiota from patients with irritable bowel syndrome alters gut function and behavior in recipient mice

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