Contents
01 March 2017
Vol 9, Issue 379
Vol 9, Issue 379
Editorial
- Rx for Innovation: A path forward for us all
The health citizenship movement can provide a platform for citizens—healthy and ill—to engage with researchers, industry, and regulators.
Research Articles
- Improved tissue cryopreservation using inductive heating of magnetic nanoparticles
A scalable technology using iron oxide nanoparticles and inductive radiofrequency heating rapidly and uniformly rewarms vitrified tissues.
- Integrated molecular analysis of tumor biopsies on sequential CTLA-4 and PD-1 blockade reveals markers of response and resistance
Profiling of melanoma patients treated with checkpoint blockade reveals TCR clonality and copy number loss as correlates of therapeutic response.
- Transplantation of fecal microbiota from patients with irritable bowel syndrome alters gut function and behavior in recipient mice
Fecal microbiota transplants from patients with irritable bowel syndrome and anxiety alter gut function and behavior in germ-free mice.
- Evolutionarily conserved serum microRNAs predict radiation-induced fatality in nonhuman primates
Evolutionarily conserved serum microRNAs predict radiation-induced fatality in nonhuman primates.
Editors' Choice
- 50 shades of red
Synthetic heart valves designed from slowly degrading polymer enable gradual replacement by new host tissue during a 12-month study in sheep.
- Turning skin “check” into checkmate
Artificial intelligence algorithm performs on par with dermatologists to distinguish malignant from benign skin tumors.
- Enhancing cognitive behavioral therapy: Is the finish line in sight?
Augmentation of cognitive behavioral therapy with D-cycloserine (DCS) for anxiety disorders results in a small decrease in symptom severity.
- Astrocytes light up glial heterogeneity
Functionally diverse subpopulations of astrocytes have correlates in the neoplastic adult brain.
About The Cover
ONLINE COVER Cryopreservation Heats Up. Storing organs and tissues at very low temperatures (cryopreservation) could help improve tissue banking for transplantation, but only if tissues can be thawed from their supercooled, glass-like (vitrified) state without damage. Manuchehrabadi et al. developed an inductive heating system, shown here, that rewarmed vitrified tissues up to 50 ml in volume. Tissues such as the blood vessel in the image were embedded in cryoprotectant solution mixed with magnetic nanoparticles. When exposed to alternating magnetic fields (arrows) induced by the radiofrequency coil, the nanoparticles generated rapid and uniform heat throughout the sample, yielding a thawed sample with preserved viability and structure. [CREDIT: ANDY GRAMS DESIGN SOLUTIONS/ANDYGRAMS.COM]
