01 March 2017
Vol 9, Issue 379

About The Cover

Cover image expansion

ONLINE COVER Cryopreservation Heats Up. Storing organs and tissues at very low temperatures (cryopreservation) could help improve tissue banking for transplantation, but only if tissues can be thawed from their supercooled, glass-like (vitrified) state without damage. Manuchehrabadi et al. developed an inductive heating system, shown here, that rewarmed vitrified tissues up to 50 ml in volume. Tissues such as the blood vessel in the image were embedded in cryoprotectant solution mixed with magnetic nanoparticles. When exposed to alternating magnetic fields (arrows) induced by the radiofrequency coil, the nanoparticles generated rapid and uniform heat throughout the sample, yielding a thawed sample with preserved viability and structure. [CREDIT: ANDY GRAMS DESIGN SOLUTIONS/ANDYGRAMS.COM]