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Loss of tumor suppressor KDM6A amplifies PRC2-regulated transcriptional repression in bladder cancer and can be targeted through inhibition of EZH2

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Science Translational Medicine  22 Feb 2017:
Vol. 9, Issue 378, eaai8312
DOI: 10.1126/scitranslmed.aai8312

Article Information

vol. 9 no. 378

PubMed: 
Print ISSN: 
Online ISSN: 
History: 
  • Received for publication September 21, 2016
  • Accepted for publication February 2, 2017

Author Information

  1. Lian Dee Ler1,2,3,
  2. Sujoy Ghosh4,5,
  3. Xiaoran Chai5,
  4. Aye Aye Thike6,
  5. Hong Lee Heng1,2,
  6. Ee Yan Siew1,2,
  7. Sucharita Dey7,
  8. Liang Kai Koh1,2,
  9. Jing Quan Lim1,2,
  10. Weng Khong Lim1,2,
  11. Swe Swe Myint1,2,
  12. Jia Liang Loh1,2,
  13. Pauline Ong1,2,
  14. Xin Xiu Sam6,
  15. Dachuan Huang1,2,
  16. Tony Lim6,
  17. Puay Hoon Tan6,
  18. Sanjanaa Nagarajan1,2,
  19. Christopher Wai Sam Cheng8,
  20. Henry Ho8,
  21. Lay Guat Ng8,
  22. John Yuen8,
  23. Po-Hung Lin9,
  24. Cheng-Keng Chuang9,
  25. Ying-Hsu Chang9,
  26. Wen-Hui Weng10,
  27. Steven G. Rozen2,5,
  28. Patrick Tan2,7,11,12,
  29. Caretha L. Creasy13,
  30. See-Tong Pang9,*,
  31. Michael T. McCabe13,*,
  32. Song Ling Poon1,2,* and
  33. Bin Tean Teh1,2,7,14,*
  1. 1Laboratory of Cancer Epigenome, Division of Medical Sciences, National Cancer Centre Singapore, 11 Hospital Drive, Singapore 169610, Singapore.
  2. 2Program in Cancer and Stem Cell Biology, Duke-NUS Medical School, 8 College Road, Singapore 169857, Singapore.
  3. 3NUS Graduate School for Integrative Sciences and Engineering, 28 Medical Drive, Singapore 117456, Singapore.
  4. 4Program in Cardiovascular and Metabolic Disorders, Duke-NUS Medical School, Singapore 169857, Singapore.
  5. 5Centre for Computational Biology, Duke-NUS Medical School, Singapore 169857, Singapore.
  6. 6Department of Pathology, Singapore General Hospital, Singapore, Singapore.
  7. 7Cancer Science Institute of Singapore, National University of Singapore, Centre for Life Sciences, Singapore 117456, Singapore.
  8. 8Department of Urology, Singapore General Hospital, Outram Road, Singapore 169608, Singapore.
  9. 9Division of Urooncology, Department of Urology, Chang Gung University and Memorial Hospital at LinKou, TaoYuan, Taiwan.
  10. 10Department of Chemical Engineering and Biotechnology and Graduate Institute of Biochemical and Biomedical Engineering, National Taipei University of Technology, Taipei, Taiwan.
  11. 11Division of Cellular and Molecular Research, National Cancer Centre Singapore, Singapore 169610, Singapore.
  12. 12Genome Institute of Singapore, 60 Biopolis Street Genome, Singapore 138672, Singapore.
  13. 13Cancer Epigenetics Discovery Performance Unit, Oncology R&D, GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, PA 19426, USA.
  14. 14Institute of Molecular and Cell Biology, 61 Biopolis Drive, Proteos, #07-18, Singapore 138673, Singapore.
  1. *Corresponding author. Email: teh.bin.tean{at}singhealth.com.sg (B.T.T.); songling.poon{at}gmail.com (S.L.P.); michael.t.mccabe{at}gsk.com (M.T.M.); jacobpang{at}adm.cgmh.org.tw (S.-T.P.)

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