Contents
22 February 2017
Vol 9, Issue 378
Vol 9, Issue 378
Research Articles
- A divergent population of autoantigen-responsive CD4+ T cells in infants prior to β cell autoimmunity
A divergent autoantigen-responsive CD4+ T cell population is present in infancy, before autoimmunity in type 1 diabetes.
- Loss of tumor suppressor KDM6A amplifies PRC2-regulated transcriptional repression in bladder cancer and can be targeted through inhibition of EZH2
Bladder cancer with loss of KDM6A expression is vulnerable to inhibition of EZH2.
- Antimicrobials from human skin commensal bacteria protect against Staphylococcus aureus and are deficient in atopic dermatitis
Commensal skin bacteria produce previously unknown antimicrobial peptides that can inhibit Staphylococcus aureus colonization of atopic dermatitis subjects.
Editors' Choice
- New near-infrared dyes light up deep tissue imaging
A newly synthesized class of near-infrared dyes offers strong absorption and efficient fluorescent emission for deep-tissue molecular imaging applications.
- Beware! Are bacteria raising your oxidative stress?
Peptostreptococcus anaerobius, enriched in patients with colon cancer, induces cellular proliferation and dysplasia by toll-like receptor (TLR) 2– and TLR4-dependent increase in oxidative stress and cholesterol biosynthesis.
- Addicted to love?
Reproductive hormones alter activity in neural circuits linking reward and social interactions.
- Porous polymeric platform repairs primates after spinal cord injury
Amine-containing polymers immobilized on mesh and placed at trauma sites scavenge biomolecules that initiate a damaging immune response.
About The Cover
ONLINE COVER Infant Islets at Risk. A sensitization period exists prior to development of autoimmunity in type 1 diabetes. Shown here is an antigen-presenting cell (red) activating a β cell–specific T cell (white and green). Heninger et al. found that children who eventually became diabetic had a population of preprimed autoreactive T cells detectable as early as 6 months of age. These results suggest that cues dictating the development of autoimmunity are happening even earlier than previously thought, potentially narrowing the window for prevention. [CREDIT: PAOLO MONTI, RCCS SAN RAFFAELE SCIENTIFIC INSTITUTE]