22 February 2017
Vol 9, Issue 378

About The Cover

Cover image expansion

ONLINE COVER Infant Islets at Risk. A sensitization period exists prior to development of autoimmunity in type 1 diabetes. Shown here is an antigen-presenting cell (red) activating a β cell–specific T cell (white and green). Heninger et al. found that children who eventually became diabetic had a population of preprimed autoreactive T cells detectable as early as 6 months of age. These results suggest that cues dictating the development of autoimmunity are happening even earlier than previously thought, potentially narrowing the window for prevention. [CREDIT: PAOLO MONTI, RCCS SAN RAFFAELE SCIENTIFIC INSTITUTE]