Research ArticleHIV
Delayed differentiation of potent effector CD8+ T cells reducing viremia and reservoir seeding in acute HIV infection
- View ORCID ProfileHiroshi Takata1,2,
- Supranee Buranapraditkun1,2,3,
- View ORCID ProfileCari Kessing4,
- James L. K. Fletcher5,
- Roshell Muir6,
- View ORCID ProfileVirginie Tardif6,
- Pearline Cartwright7,
- Claire Vandergeeten8,
- View ORCID ProfileWendy Bakeman8,
- View ORCID ProfileCarmen N. Nichols8,
- View ORCID ProfileSuteeraporn Pinyakorn1,2,
- Pokrath Hansasuta3,9,
- Eugene Kroon5,
- Thep Chalermchai5,
- Robert O’Connell10,
- View ORCID ProfileJerome Kim11,
- Nittaya Phanuphak5,
- View ORCID ProfileMerlin L. Robb1,2,
- View ORCID ProfileNelson L. Michael1,
- Nicolas Chomont12,
- View ORCID ProfileElias K. Haddad6,
- Jintanat Ananworanich1,2,5,
- View ORCID ProfileLydie Trautmann1,2,*,
- on behalf of the RV254/SEARCH010 and the RV304/SEARCH013 Study Groups
- 1U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.
- 2Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD 20817, USA.
- 3Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
- 4The Scripps Research Institute, Jupiter, FL 33458, USA.
- 5SEARCH, The Thai Red Cross AIDS Research Centre, Bangkok, Thailand.
- 6Department of Medicine, Division of Infectious Diseases and HIV Medicine, Drexel University, Philadelphia, PA 19102, USA.
- 7School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA.
- 8Vaccine and Gene Therapy Institute of Florida, Port St. Lucie, FL 34987, USA.
- 9Nuffield Department of Medicine, University of Oxford, Oxford, U.K.
- 10Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand.
- 11International Vaccine Institute, Seoul, Republic of Korea.
- 12Department of Microbiology, Infectiology, and Immunology, Centre de Recherche Hospitalier de l’Université de Montréal, Université de Montréal, Montréal, Quebec, Canada.
- ↵*Corresponding author. Email: ltrautmann{at}hivresearch.org
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Science Translational Medicine 15 Feb 2017:
Vol. 9, Issue 377, eaag1809
DOI: 10.1126/scitranslmed.aag1809
Vol. 9, Issue 377, eaag1809
DOI: 10.1126/scitranslmed.aag1809
Hiroshi Takata
1U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.
2Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD 20817, USA.
Supranee Buranapraditkun
1U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.
2Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD 20817, USA.
3Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
Cari Kessing
4The Scripps Research Institute, Jupiter, FL 33458, USA.
James L. K. Fletcher
5SEARCH, The Thai Red Cross AIDS Research Centre, Bangkok, Thailand.
Roshell Muir
6Department of Medicine, Division of Infectious Diseases and HIV Medicine, Drexel University, Philadelphia, PA 19102, USA.
Virginie Tardif
6Department of Medicine, Division of Infectious Diseases and HIV Medicine, Drexel University, Philadelphia, PA 19102, USA.
Pearline Cartwright
7School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA.
Claire Vandergeeten
8Vaccine and Gene Therapy Institute of Florida, Port St. Lucie, FL 34987, USA.
Wendy Bakeman
8Vaccine and Gene Therapy Institute of Florida, Port St. Lucie, FL 34987, USA.
Carmen N. Nichols
8Vaccine and Gene Therapy Institute of Florida, Port St. Lucie, FL 34987, USA.
Suteeraporn Pinyakorn
1U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.
2Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD 20817, USA.
Pokrath Hansasuta
3Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
9Nuffield Department of Medicine, University of Oxford, Oxford, U.K.
Eugene Kroon
5SEARCH, The Thai Red Cross AIDS Research Centre, Bangkok, Thailand.
Thep Chalermchai
5SEARCH, The Thai Red Cross AIDS Research Centre, Bangkok, Thailand.
Robert O’Connell
10Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand.
Jerome Kim
11International Vaccine Institute, Seoul, Republic of Korea.
Nittaya Phanuphak
5SEARCH, The Thai Red Cross AIDS Research Centre, Bangkok, Thailand.
Merlin L. Robb
1U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.
2Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD 20817, USA.
Nelson L. Michael
1U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.
Nicolas Chomont
12Department of Microbiology, Infectiology, and Immunology, Centre de Recherche Hospitalier de l’Université de Montréal, Université de Montréal, Montréal, Quebec, Canada.
Elias K. Haddad
6Department of Medicine, Division of Infectious Diseases and HIV Medicine, Drexel University, Philadelphia, PA 19102, USA.
Jintanat Ananworanich
1U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.
2Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD 20817, USA.
5SEARCH, The Thai Red Cross AIDS Research Centre, Bangkok, Thailand.
Lydie Trautmann
1U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.
2Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD 20817, USA.
