Research ArticleHIV
Delayed differentiation of potent effector CD8+ T cells reducing viremia and reservoir seeding in acute HIV infection
- Hiroshi Takata1,2,
- Supranee Buranapraditkun1,2,3,
- Cari Kessing4,
- James L. K. Fletcher5,
- Roshell Muir6,
- Virginie Tardif6,
- Pearline Cartwright7,
- Claire Vandergeeten8,
- Wendy Bakeman8,
- Carmen N. Nichols8,
- Suteeraporn Pinyakorn1,2,
- Pokrath Hansasuta3,9,
- Eugene Kroon5,
- Thep Chalermchai5,
- Robert O’Connell10,
- Jerome Kim11,
- Nittaya Phanuphak5,
- Merlin L. Robb1,2,
- Nelson L. Michael1,
- Nicolas Chomont12,
- Elias K. Haddad6,
- Jintanat Ananworanich1,2,5,
- Lydie Trautmann1,2,*,
- on behalf of the RV254/SEARCH010 and the RV304/SEARCH013 Study Groups
- 1U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.
- 2Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD 20817, USA.
- 3Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
- 4The Scripps Research Institute, Jupiter, FL 33458, USA.
- 5SEARCH, The Thai Red Cross AIDS Research Centre, Bangkok, Thailand.
- 6Department of Medicine, Division of Infectious Diseases and HIV Medicine, Drexel University, Philadelphia, PA 19102, USA.
- 7School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA.
- 8Vaccine and Gene Therapy Institute of Florida, Port St. Lucie, FL 34987, USA.
- 9Nuffield Department of Medicine, University of Oxford, Oxford, U.K.
- 10Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand.
- 11International Vaccine Institute, Seoul, Republic of Korea.
- 12Department of Microbiology, Infectiology, and Immunology, Centre de Recherche Hospitalier de l’Université de Montréal, Université de Montréal, Montréal, Quebec, Canada.
- ↵*Corresponding author. Email: ltrautmann{at}hivresearch.org
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Science Translational Medicine 15 Feb 2017:
Vol. 9, Issue 377, eaag1809
DOI: 10.1126/scitranslmed.aag1809
Vol. 9, Issue 377, eaag1809
DOI: 10.1126/scitranslmed.aag1809
Hiroshi Takata
U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD 20817, USA.
Supranee Buranapraditkun
U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD 20817, USA.Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
Cari Kessing
The Scripps Research Institute, Jupiter, FL 33458, USA.
James L. K. Fletcher
SEARCH, The Thai Red Cross AIDS Research Centre, Bangkok, Thailand.
Roshell Muir
Department of Medicine, Division of Infectious Diseases and HIV Medicine, Drexel University, Philadelphia, PA 19102, USA.
Virginie Tardif
Department of Medicine, Division of Infectious Diseases and HIV Medicine, Drexel University, Philadelphia, PA 19102, USA.
Pearline Cartwright
School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA.
Claire Vandergeeten
Vaccine and Gene Therapy Institute of Florida, Port St. Lucie, FL 34987, USA.
Wendy Bakeman
Vaccine and Gene Therapy Institute of Florida, Port St. Lucie, FL 34987, USA.
Carmen N. Nichols
Vaccine and Gene Therapy Institute of Florida, Port St. Lucie, FL 34987, USA.
Suteeraporn Pinyakorn
U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD 20817, USA.
Pokrath Hansasuta
Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.Nuffield Department of Medicine, University of Oxford, Oxford, U.K.
Eugene Kroon
SEARCH, The Thai Red Cross AIDS Research Centre, Bangkok, Thailand.
Thep Chalermchai
SEARCH, The Thai Red Cross AIDS Research Centre, Bangkok, Thailand.
Robert O’Connell
Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand.
Jerome Kim
International Vaccine Institute, Seoul, Republic of Korea.
Nittaya Phanuphak
SEARCH, The Thai Red Cross AIDS Research Centre, Bangkok, Thailand.
Merlin L. Robb
U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD 20817, USA.
Nelson L. Michael
U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.
Nicolas Chomont
Department of Microbiology, Infectiology, and Immunology, Centre de Recherche Hospitalier de l’Université de Montréal, Université de Montréal, Montréal, Quebec, Canada.
Elias K. Haddad
Department of Medicine, Division of Infectious Diseases and HIV Medicine, Drexel University, Philadelphia, PA 19102, USA.
Jintanat Ananworanich
U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD 20817, USA.SEARCH, The Thai Red Cross AIDS Research Centre, Bangkok, Thailand.
Lydie Trautmann
U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD 20817, USA.
