Research ArticleMicrobiome

IgA-coated E. coli enriched in Crohn’s disease spondyloarthritis promote TH17-dependent inflammation

See allHide authors and affiliations

Science Translational Medicine  08 Feb 2017:
Vol. 9, Issue 376, eaaf9655
DOI: 10.1126/scitranslmed.aaf9655

You are currently viewing the editor's summary.

View Full Text

Log in to view the full text

Log in through your institution

Log in through your institution

Pathosymbiont perturbation of immune homeostasis

The influence of the gut microbiome extends beyond the intestines and can modulate many host systems. A subset of Crohn’s disease patients also experience painful spondyloarthritis, and Viladomiu et al. discovered that the immune systems of these patients are more likely to recognize a certain kind of Escherichia coli. As colonization with this bacterium induced systemic TH17 immunity and worsened development of colitis and arthritis in mouse models, this pathosymbiont may be causing a systemic TH17-driven inflammation that leads to extraintestinal complications in Crohn’s disease patients, such as stiffness and spinal pain. Precise targeting of these types of bacteria or reversing the TH17 phenotype they induce could bring relief to patients.

View Full Text

Stay Connected to Science Translational Medicine