Contents
08 February 2017
Vol 9, Issue 376
Vol 9, Issue 376
Research Articles
- IgA-coated E. coli enriched in Crohn’s disease spondyloarthritis promote TH17-dependent inflammation
IgA-reactive E. coli in Crohn’s disease–associated spondyloarthritis link mucosal immunity and systemic inflammation.
- Drug discovery for Diamond-Blackfan anemia using reprogrammed hematopoietic progenitors
A stem cell reprogramming approach enables disease modeling and drug discovery for a genetic blood disorder and uncovers a candidate therapeutic.
- Thioredoxin reverses age-related hypertension by chronically improving vascular redox and restoring eNOS function
Thioredoxin treatment in aged mice reversed hypertension, suggesting a potential therapeutic approach.
- Intestinal commensal bacteria mediate lung mucosal immunity and promote resistance of newborn mice to infection
Postnatal colonization by intestinal commensal bacteria directs migration of innate lymphoid cells to the lungs and promotes resistance of newborn mice to pneumonia.
- Two-step enhanced cancer immunotherapy with engineered Salmonella typhimurium secreting heterologous flagellin
Engineered Salmonella secreting heterologous bacterial flagellin suppress tumor growth by activating intratumoral macrophages.
Editors' Choice
- Could a coffee a day keep the inflammasome away?
Increased expression of inflammasome-related genes predicts geriatric morbidity and mortality.
- Tell me your neighbors, and I will tell you what you are
Network neighbors improve yeast to human gene mapping for the study of parkinsonism.
- Your genes are conspiring against you
Gene variants in the dopamine receptor D2 expression network predict physiological and clinical features as well as treatment responses in schizophrenia.
- Antiangiogenic cancer drug drives lymphangiogenic metastasis
Tumor blood vessel–destroying cancer drug induces development of tumor lymphatics that contribute to treatment failure.
About The Cover
ONLINE COVER E. coli Spreads Its Influence. Although most gut bacteria go unnoticed by the immune system, certain species have been shown to modulate host immunity. Viladomiu et al. analyzed Escherichia coli bacteria recognized by the immune system in patients with Crohn's disease with or without associated spondyloarthritis. They discovered a particular strain of E. coli was more likely to prompt an immune reaction in the patients with spondyloarthritis. Shown here are fluorescently labeled bacteria in a mouse gut colonized with this E. coli strain, which the authors demonstrate induces TH17 immunity in the mice. It is possible that recognition of this E. coli strain contributes to the development of spondyloarthritis in patients with Crohn's disease. [CREDIT: KENNETH SIMPSON/CORNELL UNIVERSITY]
