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Research ArticleCancer
2-Hydroxyglutarate produced by neomorphic IDH mutations suppresses homologous recombination and induces PARP inhibitor sensitivity
- Parker L. Sulkowski1,2,*,
- Christopher D. Corso1,*,
- Nathaniel D. Robinson1,
- Susan E. Scanlon1,3,
- Karin R. Purshouse1,
- Hanwen Bai2,
- Yanfeng Liu1,
- Ranjini K. Sundaram1,
- Denise C. Hegan1,
- Nathan R. Fons1,3,
- Gregory A. Breuer1,3,
- Yuanbin Song4,
- Ketu Mishra-Gorur5,
- Henk M. De Feyter6,
- Robin A. de Graaf6,
- Yulia V. Surovtseva7,
- Maureen Kachman8,
- Stephanie Halene4,
- Murat Günel2,5,
- Peter M. Glazer1,2,† and
- Ranjit S. Bindra1,3,†
- 1Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, CT 06520, USA.
- 2Department of Genetics, Yale University School of Medicine, New Haven, CT 06520, USA.
- 3Department of Experimental Pathology, Yale University School of Medicine, New Haven, CT 06520, USA.
- 4Section of Hematology, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, USA.
- 5Department of Neurosurgery, Yale University School of Medicine, New Haven, CT 06520, USA.
- 6Department of Radiology and Biomedical Imaging, Yale University School of Medicine, New Haven, CT 06520, USA.
- 7Yale Center for Molecular Discovery, West Haven, CT 06516, USA.
- 8Michigan Regional Comprehensive Metabolomics Resource Core, National Institute of Environmental Health Sciences (NIEHS) Children’s Health Exposure Analysis Resource for Metabolomics, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
- ↵†Corresponding author. Email: ranjit.bindra{at}yale.edu (R.S.B.); peter.glazer{at}yale.edu (P.M.G.)
↵* These authors contributed equally to this work.
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Science Translational Medicine 01 Feb 2017:
Vol. 9, Issue 375, eaal2463
DOI: 10.1126/scitranslmed.aal2463
Vol. 9, Issue 375, eaal2463
DOI: 10.1126/scitranslmed.aal2463
Parker L. Sulkowski
1Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, CT 06520, USA.
2Department of Genetics, Yale University School of Medicine, New Haven, CT 06520, USA.
Christopher D. Corso
1Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, CT 06520, USA.
Nathaniel D. Robinson
1Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, CT 06520, USA.
Susan E. Scanlon
1Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, CT 06520, USA.
3Department of Experimental Pathology, Yale University School of Medicine, New Haven, CT 06520, USA.
Karin R. Purshouse
1Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, CT 06520, USA.
Hanwen Bai
2Department of Genetics, Yale University School of Medicine, New Haven, CT 06520, USA.
Yanfeng Liu
1Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, CT 06520, USA.
Ranjini K. Sundaram
1Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, CT 06520, USA.
Denise C. Hegan
1Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, CT 06520, USA.
Nathan R. Fons
1Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, CT 06520, USA.
3Department of Experimental Pathology, Yale University School of Medicine, New Haven, CT 06520, USA.
Gregory A. Breuer
1Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, CT 06520, USA.
3Department of Experimental Pathology, Yale University School of Medicine, New Haven, CT 06520, USA.
Yuanbin Song
4Section of Hematology, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, USA.
Ketu Mishra-Gorur
5Department of Neurosurgery, Yale University School of Medicine, New Haven, CT 06520, USA.
Henk M. De Feyter
6Department of Radiology and Biomedical Imaging, Yale University School of Medicine, New Haven, CT 06520, USA.
Robin A. de Graaf
6Department of Radiology and Biomedical Imaging, Yale University School of Medicine, New Haven, CT 06520, USA.
Yulia V. Surovtseva
7Yale Center for Molecular Discovery, West Haven, CT 06516, USA.
Maureen Kachman
8Michigan Regional Comprehensive Metabolomics Resource Core, National Institute of Environmental Health Sciences (NIEHS) Children’s Health Exposure Analysis Resource for Metabolomics, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Stephanie Halene
4Section of Hematology, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, USA.
Murat Günel
2Department of Genetics, Yale University School of Medicine, New Haven, CT 06520, USA.
5Department of Neurosurgery, Yale University School of Medicine, New Haven, CT 06520, USA.
Peter M. Glazer
1Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, CT 06520, USA.
2Department of Genetics, Yale University School of Medicine, New Haven, CT 06520, USA.
Ranjit S. Bindra
1Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, CT 06520, USA.
3Department of Experimental Pathology, Yale University School of Medicine, New Haven, CT 06520, USA.
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