Research ArticleCancer

2-Hydroxyglutarate produced by neomorphic IDH mutations suppresses homologous recombination and induces PARP inhibitor sensitivity

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Science Translational Medicine  01 Feb 2017:
Vol. 9, Issue 375, eaal2463
DOI: 10.1126/scitranslmed.aal2463

Article Information

vol. 9 no. 375

PubMed: 
Print ISSN: 
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History: 
  • Received for publication October 19, 2016
  • Resubmitted December 8, 2016
  • Accepted for publication December 23, 2016
  • .

Author Information

  1. Parker L. Sulkowski1,2,*,
  2. Christopher D. Corso1,*,
  3. Nathaniel D. Robinson1,
  4. Susan E. Scanlon1,3,
  5. Karin R. Purshouse1,
  6. Hanwen Bai2,
  7. Yanfeng Liu1,
  8. Ranjini K. Sundaram1,
  9. Denise C. Hegan1,
  10. Nathan R. Fons1,3,
  11. Gregory A. Breuer1,3,
  12. Yuanbin Song4,
  13. Ketu Mishra-Gorur5,
  14. Henk M. De Feyter6,
  15. Robin A. de Graaf6,
  16. Yulia V. Surovtseva7,
  17. Maureen Kachman8,
  18. Stephanie Halene4,
  19. Murat Günel2,5,
  20. Peter M. Glazer1,2, and
  21. Ranjit S. Bindra1,3,
  1. 1Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, CT 06520, USA.
  2. 2Department of Genetics, Yale University School of Medicine, New Haven, CT 06520, USA.
  3. 3Department of Experimental Pathology, Yale University School of Medicine, New Haven, CT 06520, USA.
  4. 4Section of Hematology, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, USA.
  5. 5Department of Neurosurgery, Yale University School of Medicine, New Haven, CT 06520, USA.
  6. 6Department of Radiology and Biomedical Imaging, Yale University School of Medicine, New Haven, CT 06520, USA.
  7. 7Yale Center for Molecular Discovery, West Haven, CT 06516, USA.
  8. 8Michigan Regional Comprehensive Metabolomics Resource Core, National Institute of Environmental Health Sciences (NIEHS) Children’s Health Exposure Analysis Resource for Metabolomics, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
  1. Corresponding author. Email: ranjit.bindra{at}yale.edu (R.S.B.); peter.glazer{at}yale.edu (P.M.G.)
    • * These authors contributed equally to this work.

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