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Research ArticleHypertension
Platelet-localized FXI promotes a vascular coagulation-inflammatory circuit in arterial hypertension
- Sabine Kossmann1,2,*,
- Jeremy Lagrange1,*,
- Sven Jäckel1,†,
- Kerstin Jurk1,†,
- Moritz Ehlken1,2,†,
- Tanja Schönfelder1,
- Yvonne Weihert2,
- Maike Knorr2,
- Moritz Brandt2,
- Ning Xia3,
- Huige Li3,
- Andreas Daiber2,
- Matthias Oelze2,
- Christoph Reinhardt1,
- Karl Lackner4,
- Andras Gruber5,6,
- Brett Monia7,
- Susanne H. Karbach2,
- Ulrich Walter1,
- Zaverio M. Ruggeri8,
- Thomas Renné9,10,
- Wolfram Ruf1,11,12,
- Thomas Münzel2,12 and
- Philip Wenzel1,2,12,‡
- 1Center for Thrombosis and Hemostasis Mainz, University Medical Center Mainz, Langenbeckstrasse 1, 55131 Mainz, Germany.
- 2Center for Cardiology, Cardiology I, University Medical Center Mainz, 55131 Mainz, Germany.
- 3Department of Pharmacology, University Medical Center Mainz, 55131 Mainz, Germany.
- 4Institute of Clinical Chemistry and Laboratory Medicine, University Medical Center Mainz, 55131 Mainz, Germany.
- 5Department of Biomedical Engineering, Oregon Health and Science University, 3303 Southwest Bond Avenue, CH13B, Portland, OR 97239, USA.
- 6Aronora Inc., 4640 Southwest Macadam Avenue, Suite 200A, Portland, OR 97239, USA.
- 7Ionis Pharmaceuticals Inc., 2855 Gazelle Court, Carlsbad, CA 92010, USA.
- 8Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.
- 9Department of Molecular Medicine and Surgery, L1:00, Karolinska Institutet, SE-171 71 Stockholm, Sweden.
- 10Institute of Clinical Chemistry and Laboratory Medicine, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany.
- 11Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA.
- 12DZHK (German Center for Cardiovascular Research), Partner Site Rhine Main, University Medical Center Mainz, 55131 Mainz, Germany.
- ↵‡Corresponding author. Email: wenzelp{at}uni-mainz.de
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Science Translational Medicine 01 Feb 2017:
Vol. 9, Issue 375, eaah4923
DOI: 10.1126/scitranslmed.aah4923
Vol. 9, Issue 375, eaah4923
DOI: 10.1126/scitranslmed.aah4923
Sabine Kossmann
1Center for Thrombosis and Hemostasis Mainz, University Medical Center Mainz, Langenbeckstrasse 1, 55131 Mainz, Germany.
2Center for Cardiology, Cardiology I, University Medical Center Mainz, 55131 Mainz, Germany.
Jeremy Lagrange
1Center for Thrombosis and Hemostasis Mainz, University Medical Center Mainz, Langenbeckstrasse 1, 55131 Mainz, Germany.
Sven Jäckel
1Center for Thrombosis and Hemostasis Mainz, University Medical Center Mainz, Langenbeckstrasse 1, 55131 Mainz, Germany.
Kerstin Jurk
1Center for Thrombosis and Hemostasis Mainz, University Medical Center Mainz, Langenbeckstrasse 1, 55131 Mainz, Germany.
Moritz Ehlken
1Center for Thrombosis and Hemostasis Mainz, University Medical Center Mainz, Langenbeckstrasse 1, 55131 Mainz, Germany.
2Center for Cardiology, Cardiology I, University Medical Center Mainz, 55131 Mainz, Germany.
Tanja Schönfelder
1Center for Thrombosis and Hemostasis Mainz, University Medical Center Mainz, Langenbeckstrasse 1, 55131 Mainz, Germany.
Yvonne Weihert
2Center for Cardiology, Cardiology I, University Medical Center Mainz, 55131 Mainz, Germany.
Maike Knorr
2Center for Cardiology, Cardiology I, University Medical Center Mainz, 55131 Mainz, Germany.
Moritz Brandt
2Center for Cardiology, Cardiology I, University Medical Center Mainz, 55131 Mainz, Germany.
Ning Xia
3Department of Pharmacology, University Medical Center Mainz, 55131 Mainz, Germany.
Huige Li
3Department of Pharmacology, University Medical Center Mainz, 55131 Mainz, Germany.
Andreas Daiber
2Center for Cardiology, Cardiology I, University Medical Center Mainz, 55131 Mainz, Germany.
Matthias Oelze
2Center for Cardiology, Cardiology I, University Medical Center Mainz, 55131 Mainz, Germany.
Christoph Reinhardt
1Center for Thrombosis and Hemostasis Mainz, University Medical Center Mainz, Langenbeckstrasse 1, 55131 Mainz, Germany.
Karl Lackner
4Institute of Clinical Chemistry and Laboratory Medicine, University Medical Center Mainz, 55131 Mainz, Germany.
Andras Gruber
5Department of Biomedical Engineering, Oregon Health and Science University, 3303 Southwest Bond Avenue, CH13B, Portland, OR 97239, USA.
6Aronora Inc., 4640 Southwest Macadam Avenue, Suite 200A, Portland, OR 97239, USA.
Brett Monia
7Ionis Pharmaceuticals Inc., 2855 Gazelle Court, Carlsbad, CA 92010, USA.
Susanne H. Karbach
2Center for Cardiology, Cardiology I, University Medical Center Mainz, 55131 Mainz, Germany.
Ulrich Walter
1Center for Thrombosis and Hemostasis Mainz, University Medical Center Mainz, Langenbeckstrasse 1, 55131 Mainz, Germany.
Zaverio M. Ruggeri
8Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.
Thomas Renné
9Department of Molecular Medicine and Surgery, L1:00, Karolinska Institutet, SE-171 71 Stockholm, Sweden.
10Institute of Clinical Chemistry and Laboratory Medicine, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany.
Wolfram Ruf
1Center for Thrombosis and Hemostasis Mainz, University Medical Center Mainz, Langenbeckstrasse 1, 55131 Mainz, Germany.
11Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA.
12DZHK (German Center for Cardiovascular Research), Partner Site Rhine Main, University Medical Center Mainz, 55131 Mainz, Germany.
Thomas Münzel
2Center for Cardiology, Cardiology I, University Medical Center Mainz, 55131 Mainz, Germany.
12DZHK (German Center for Cardiovascular Research), Partner Site Rhine Main, University Medical Center Mainz, 55131 Mainz, Germany.
Philip Wenzel
1Center for Thrombosis and Hemostasis Mainz, University Medical Center Mainz, Langenbeckstrasse 1, 55131 Mainz, Germany.
2Center for Cardiology, Cardiology I, University Medical Center Mainz, 55131 Mainz, Germany.
12DZHK (German Center for Cardiovascular Research), Partner Site Rhine Main, University Medical Center Mainz, 55131 Mainz, Germany.
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