Platelet-localized FXI promotes a vascular coagulation-inflammatory circuit in arterial hypertension

Sabine Kossmann; Jeremy Lagrange; Sven Jäckel; Kerstin Jurk; Moritz Ehlken; Tanja Schönfelder; Yvonne Weihert; Maike Knorr; Moritz Brandt; Ning Xia; Huige Li; Andreas Daiber; Matthias Oelze; Christoph Reinhardt; Karl Lackner; Andras Gruber; Brett Monia; Susanne H. Karbach; Ulrich Walter; Zaverio M. Ruggeri; Thomas Renné; Wolfram Ruf; Thomas Münzel; Philip Wenzel

doi:10.1126/scitranslmed.aah4923

Research ArticleHypertension

Platelet-localized FXI promotes a vascular coagulation-inflammatory circuit in arterial hypertension

Sabine Kossmann¹,²,*,
Jeremy Lagrange¹,*,
Sven Jäckel¹,†,
Kerstin Jurk¹,†,
Moritz Ehlken¹,²,†,
Tanja Schönfelder¹,
Yvonne Weihert²,
Maike Knorr²,
Moritz Brandt²,
Ning Xia³,
Huige Li³,
Andreas Daiber²,
Matthias Oelze²,
Christoph Reinhardt¹,
Karl Lackner⁴,
Andras Gruber⁵,⁶,
Brett Monia⁷,
Susanne H. Karbach²,
Ulrich Walter¹,
Zaverio M. Ruggeri⁸,
Thomas Renné⁹,¹⁰,
Wolfram Ruf¹,¹¹,¹²,
Thomas Münzel²,¹² and
Philip Wenzel¹,²,¹²,‡

¹Center for Thrombosis and Hemostasis Mainz, University Medical Center Mainz, Langenbeckstrasse 1, 55131 Mainz, Germany.
²Center for Cardiology, Cardiology I, University Medical Center Mainz, 55131 Mainz, Germany.
³Department of Pharmacology, University Medical Center Mainz, 55131 Mainz, Germany.
⁴Institute of Clinical Chemistry and Laboratory Medicine, University Medical Center Mainz, 55131 Mainz, Germany.
⁵Department of Biomedical Engineering, Oregon Health and Science University, 3303 Southwest Bond Avenue, CH13B, Portland, OR 97239, USA.
⁶Aronora Inc., 4640 Southwest Macadam Avenue, Suite 200A, Portland, OR 97239, USA.
⁷Ionis Pharmaceuticals Inc., 2855 Gazelle Court, Carlsbad, CA 92010, USA.
⁸Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.
⁹Department of Molecular Medicine and Surgery, L1:00, Karolinska Institutet, SE-171 71 Stockholm, Sweden.
¹⁰Institute of Clinical Chemistry and Laboratory Medicine, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany.
¹¹Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA.
¹²DZHK (German Center for Cardiovascular Research), Partner Site Rhine Main, University Medical Center Mainz, 55131 Mainz, Germany.

↵‡Corresponding author. Email: wenzelp{at}uni-mainz.de

↵* These authors contributed equally as first authors.
↵† These authors contributed equally as second authors.

See allHide authors and affiliations

Science Translational Medicine 01 Feb 2017:
Vol. 9, Issue 375, eaah4923
DOI: 10.1126/scitranslmed.aah4923

Sabine Kossmann

1Center for Thrombosis and Hemostasis Mainz, University Medical Center Mainz, Langenbeckstrasse 1, 55131 Mainz, Germany.

2Center for Cardiology, Cardiology I, University Medical Center Mainz, 55131 Mainz, Germany.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Jeremy Lagrange

1Center for Thrombosis and Hemostasis Mainz, University Medical Center Mainz, Langenbeckstrasse 1, 55131 Mainz, Germany.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Sven Jäckel

1Center for Thrombosis and Hemostasis Mainz, University Medical Center Mainz, Langenbeckstrasse 1, 55131 Mainz, Germany.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Kerstin Jurk

1Center for Thrombosis and Hemostasis Mainz, University Medical Center Mainz, Langenbeckstrasse 1, 55131 Mainz, Germany.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Moritz Ehlken

1Center for Thrombosis and Hemostasis Mainz, University Medical Center Mainz, Langenbeckstrasse 1, 55131 Mainz, Germany.

2Center for Cardiology, Cardiology I, University Medical Center Mainz, 55131 Mainz, Germany.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Tanja Schönfelder

1Center for Thrombosis and Hemostasis Mainz, University Medical Center Mainz, Langenbeckstrasse 1, 55131 Mainz, Germany.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Yvonne Weihert

2Center for Cardiology, Cardiology I, University Medical Center Mainz, 55131 Mainz, Germany.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Maike Knorr

2Center for Cardiology, Cardiology I, University Medical Center Mainz, 55131 Mainz, Germany.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Moritz Brandt

2Center for Cardiology, Cardiology I, University Medical Center Mainz, 55131 Mainz, Germany.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Ning Xia

3Department of Pharmacology, University Medical Center Mainz, 55131 Mainz, Germany.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Huige Li

3Department of Pharmacology, University Medical Center Mainz, 55131 Mainz, Germany.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Andreas Daiber

2Center for Cardiology, Cardiology I, University Medical Center Mainz, 55131 Mainz, Germany.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Matthias Oelze

2Center for Cardiology, Cardiology I, University Medical Center Mainz, 55131 Mainz, Germany.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Christoph Reinhardt

1Center for Thrombosis and Hemostasis Mainz, University Medical Center Mainz, Langenbeckstrasse 1, 55131 Mainz, Germany.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Karl Lackner

4Institute of Clinical Chemistry and Laboratory Medicine, University Medical Center Mainz, 55131 Mainz, Germany.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Andras Gruber

5Department of Biomedical Engineering, Oregon Health and Science University, 3303 Southwest Bond Avenue, CH13B, Portland, OR 97239, USA.

6Aronora Inc., 4640 Southwest Macadam Avenue, Suite 200A, Portland, OR 97239, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Brett Monia

7Ionis Pharmaceuticals Inc., 2855 Gazelle Court, Carlsbad, CA 92010, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Susanne H. Karbach

2Center for Cardiology, Cardiology I, University Medical Center Mainz, 55131 Mainz, Germany.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Ulrich Walter

1Center for Thrombosis and Hemostasis Mainz, University Medical Center Mainz, Langenbeckstrasse 1, 55131 Mainz, Germany.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Zaverio M. Ruggeri

8Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Thomas Renné

9Department of Molecular Medicine and Surgery, L1:00, Karolinska Institutet, SE-171 71 Stockholm, Sweden.

10Institute of Clinical Chemistry and Laboratory Medicine, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Wolfram Ruf

1Center for Thrombosis and Hemostasis Mainz, University Medical Center Mainz, Langenbeckstrasse 1, 55131 Mainz, Germany.

11Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA.

12DZHK (German Center for Cardiovascular Research), Partner Site Rhine Main, University Medical Center Mainz, 55131 Mainz, Germany.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Thomas Münzel

2Center for Cardiology, Cardiology I, University Medical Center Mainz, 55131 Mainz, Germany.

12DZHK (German Center for Cardiovascular Research), Partner Site Rhine Main, University Medical Center Mainz, 55131 Mainz, Germany.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Philip Wenzel

1Center for Thrombosis and Hemostasis Mainz, University Medical Center Mainz, Langenbeckstrasse 1, 55131 Mainz, Germany.

2Center for Cardiology, Cardiology I, University Medical Center Mainz, 55131 Mainz, Germany.

12DZHK (German Center for Cardiovascular Research), Partner Site Rhine Main, University Medical Center Mainz, 55131 Mainz, Germany.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
For correspondence: wenzelp@uni-mainz.de

Article
Figures & Data
Info & Metrics
eLetters
PDF

eLetters is an online forum for ongoing peer review. Submission of eLetters are open to all. Please read our Terms of Service before submitting your own eLetter.

Submit a Response to This Article

Compose eLetter

Title

Contents

More information about text formats

Plain text

Plain text
No HTML tags allowed.
Web page addresses and e-mail addresses turn into links automatically.
Lines and paragraphs break automatically.

Author Information

Contributors
First name and middle name First or given name, e.g. 'Peter'. Last Name Your last, or family, name, e.g. 'MacMoody'. Email Your email address, e.g. higgs-boson@gmail.com Role / Occupation Your role and/or occupation, e.g. 'Orthopedic Surgeon'. Affiliation Your organization or institution (if applicable), e.g. 'Royal Free Hospital'.

Statement of Competing Interests

Competing interests?

Yes

Please describe the competing interests

CAPTCHA

This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.

Vertical Tabs

No eLetters have been published for this article.

View Full Text

Platelet-localized FXI promotes a vascular coagulation-inflammatory circuit in arterial hypertension

Plain text

Vertical Tabs

Science Translational Medicine

Article Tools