Research ArticleHypertension

Platelet-localized FXI promotes a vascular coagulation-inflammatory circuit in arterial hypertension

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Science Translational Medicine  01 Feb 2017:
Vol. 9, Issue 375, eaah4923
DOI: 10.1126/scitranslmed.aah4923

Article Information

vol. 9 no. 375

PubMed: 
Print ISSN: 
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History: 
  • Received for publication October 26, 2015
  • Resubmitted July 5, 2016
  • Accepted for publication December 12, 2016
  • .

Author Information

  1. Sabine Kossmann1,2,*,
  2. Jeremy Lagrange1,*,
  3. Sven Jäckel1,,
  4. Kerstin Jurk1,,
  5. Moritz Ehlken1,2,,
  6. Tanja Schönfelder1,
  7. Yvonne Weihert2,
  8. Maike Knorr2,
  9. Moritz Brandt2,
  10. Ning Xia3,
  11. Huige Li3,
  12. Andreas Daiber2,
  13. Matthias Oelze2,
  14. Christoph Reinhardt1,
  15. Karl Lackner4,
  16. Andras Gruber5,6,
  17. Brett Monia7,
  18. Susanne H. Karbach2,
  19. Ulrich Walter1,
  20. Zaverio M. Ruggeri8,
  21. Thomas Renné9,10,
  22. Wolfram Ruf1,11,12,
  23. Thomas Münzel2,12 and
  24. Philip Wenzel1,2,12,
  1. 1Center for Thrombosis and Hemostasis Mainz, University Medical Center Mainz, Langenbeckstrasse 1, 55131 Mainz, Germany.
  2. 2Center for Cardiology, Cardiology I, University Medical Center Mainz, 55131 Mainz, Germany.
  3. 3Department of Pharmacology, University Medical Center Mainz, 55131 Mainz, Germany.
  4. 4Institute of Clinical Chemistry and Laboratory Medicine, University Medical Center Mainz, 55131 Mainz, Germany.
  5. 5Department of Biomedical Engineering, Oregon Health and Science University, 3303 Southwest Bond Avenue, CH13B, Portland, OR 97239, USA.
  6. 6Aronora Inc., 4640 Southwest Macadam Avenue, Suite 200A, Portland, OR 97239, USA.
  7. 7Ionis Pharmaceuticals Inc., 2855 Gazelle Court, Carlsbad, CA 92010, USA.
  8. 8Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.
  9. 9Department of Molecular Medicine and Surgery, L1:00, Karolinska Institutet, SE-171 71 Stockholm, Sweden.
  10. 10Institute of Clinical Chemistry and Laboratory Medicine, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany.
  11. 11Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA.
  12. 12DZHK (German Center for Cardiovascular Research), Partner Site Rhine Main, University Medical Center Mainz, 55131 Mainz, Germany.
  1. Corresponding author. Email: wenzelp{at}uni-mainz.de
    • * These authors contributed equally as first authors.

    • These authors contributed equally as second authors.

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