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Research ArticleEMERGING INFECTIONS
Therapy with CTLA4-Ig and an antiviral monoclonal antibody controls chikungunya virus arthritis
- Jonathan J. Miner1,2,3,*,
- Lindsey E. Cook2,*,
- Jun P. Hong1,
- Amber M. Smith1,
- Justin M. Richner1,
- Raeann M. Shimak1,†,
- Alissa R. Young3,
- Kristen Monte1,
- Subhajit Poddar2,
- James E. Crowe Jr4,5,6,
- Deborah J. Lenschow1,2,3,‡ and
- Michael S. Diamond1,2,3,7,‡
- 1Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.
- 2Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.
- 3Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110, USA.
- 4Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
- 5Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
- 6Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
- 7Center for Human Immunology and Immunotherapy Programs, Washington University School of Medicine, St. Louis, MO 63110, USA.
- ↵‡Corresponding author. Email: diamond{at}borcim.wustl.edu (M.S.D.); dlenschow{at}wustl.edu (D.J.L.)
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Science Translational Medicine 01 Feb 2017:
Vol. 9, Issue 375, eaah3438
DOI: 10.1126/scitranslmed.aah3438
Vol. 9, Issue 375, eaah3438
DOI: 10.1126/scitranslmed.aah3438
Jonathan J. Miner
1Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.
2Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.
3Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Lindsey E. Cook
2Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Jun P. Hong
1Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.
Amber M. Smith
1Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.
Justin M. Richner
1Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.
Raeann M. Shimak
1Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.
Alissa R. Young
3Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Kristen Monte
1Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.
Subhajit Poddar
2Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.
James E. Crowe Jr
4Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
5Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
6Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Deborah J. Lenschow
1Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.
2Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.
3Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Michael S. Diamond
1Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.
2Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.
3Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110, USA.
7Center for Human Immunology and Immunotherapy Programs, Washington University School of Medicine, St. Louis, MO 63110, USA.
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