Therapy with CTLA4-Ig and an antiviral monoclonal antibody controls chikungunya virus arthritis

Jonathan J. Miner; Lindsey E. Cook; Jun P. Hong; Amber M. Smith; Justin M. Richner; Raeann M. Shimak; Alissa R. Young; Kristen Monte; Subhajit Poddar; James E. Crowe; Deborah J. Lenschow; Michael S. Diamond

doi:10.1126/scitranslmed.aah3438

Research ArticleEMERGING INFECTIONS

Therapy with CTLA4-Ig and an antiviral monoclonal antibody controls chikungunya virus arthritis

Jonathan J. Miner¹,²,³,*,
Lindsey E. Cook²,*,
Jun P. Hong¹,
Amber M. Smith¹,
Justin M. Richner¹,
Raeann M. Shimak¹,†,
Alissa R. Young³,
Kristen Monte¹,
Subhajit Poddar²,
James E. Crowe Jr⁴,⁵,⁶,
Deborah J. Lenschow¹,²,³,‡ and
Michael S. Diamond¹,²,³,⁷,‡

¹Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.
²Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.
³Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110, USA.
⁴Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
⁵Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
⁶Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
⁷Center for Human Immunology and Immunotherapy Programs, Washington University School of Medicine, St. Louis, MO 63110, USA.

↵‡Corresponding author. Email: diamond{at}borcim.wustl.edu (M.S.D.); dlenschow{at}wustl.edu (D.J.L.)

↵* These authors contributed equally to this work.
↵† Present address: University of Kansas Cancer Center, Kansas City, KS 66160, USA.

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Science Translational Medicine 01 Feb 2017:
Vol. 9, Issue 375, eaah3438
DOI: 10.1126/scitranslmed.aah3438

Jonathan J. Miner

1Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.

2Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.

3Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110, USA.

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Lindsey E. Cook

2Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.

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Jun P. Hong

1Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.

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Amber M. Smith

1Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.

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Justin M. Richner

1Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.

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Raeann M. Shimak

1Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.

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Alissa R. Young

3Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110, USA.

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Kristen Monte

1Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.

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Subhajit Poddar

2Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.

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James E. Crowe Jr

4Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN 37232, USA.

5Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN 37232, USA.

6Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232, USA.

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Deborah J. Lenschow

1Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.

2Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.

3Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110, USA.

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For correspondence: diamond@borcim.wustl.edu dlenschow@wustl.edu

Michael S. Diamond

1Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.

2Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.

3Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110, USA.

7Center for Human Immunology and Immunotherapy Programs, Washington University School of Medicine, St. Louis, MO 63110, USA.

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For correspondence: diamond@borcim.wustl.edu dlenschow@wustl.edu

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Therapy with CTLA4-Ig and an antiviral monoclonal antibody controls chikungunya virus arthritis

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