01 February 2017
Vol 9, Issue 375

About The Cover

Cover image expansion

ONLINE COVER Brainy Skin Cells. Neural stem cells can home to brain tumors and deliver therapeutics. Unfortunately, isolating and customizing neural stem cells for each patient is not feasible, and treatment with donor stem cells requires immunosuppression. Bagó et al. came up with a more practical approach to this problem, showing that a patient's skin cells can be converted to neural stem cells and engineered to attack brain tumors. The image depicts engineered DNA molecules going into the cells, the conversion from skin to neural stem cells, and their subsequent delivery to the brain. [CREDIT: ELLA MARUSHCHENKO]