RON kinase: A target for treatment of cancer-induced bone destruction and osteoporosis

Kelsi Andrade; Jaime Fornetti; Ling Zhao; Scott C. Miller; R. Lor Randall; Neysi Anderson; Susan E. Waltz; Mark McHale; Alana L. Welm

doi:10.1126/scitranslmed.aai9338

Research ArticleBONE DEGENERATION

RON kinase: A target for treatment of cancer-induced bone destruction and osteoporosis

Kelsi Andrade¹,*,†,
Jaime Fornetti¹,*,
Ling Zhao¹,
Scott C. Miller²,
R. Lor Randall³,
Neysi Anderson¹,
Susan E. Waltz⁴,
Mark McHale⁵ and
Alana L. Welm¹,‡

¹Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT 84112, USA.
²Department of Radiology and Imaging Sciences, Division of Radiobiology, University of Utah, Salt Lake City, UT 84112, USA.
³Department of Orthopaedics, University of Utah, Salt Lake City, UT 84112, USA.
⁴Department of Cancer and Cell Biology, University of Cincinnati and Cincinnati Veterans Affairs Medical Center, Cincinnati, OH 45267, USA.
⁵Aslan Pharmaceuticals, Singapore 089824, Singapore.

↵‡Corresponding author. Email: alana.welm{at}hci.utah.edu

↵* These authors contributed equally to this work.
↵† Present address: Stephenson Cancer Center, University of Oklahoma Health Science Center, Oklahoma City, OK 73014, USA.

See allHide authors and affiliations

Science Translational Medicine 25 Jan 2017:
Vol. 9, Issue 374, eaai9338
DOI: 10.1126/scitranslmed.aai9338

Kelsi Andrade

Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT 84112, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Jaime Fornetti

Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT 84112, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Ling Zhao

Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT 84112, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Scott C. Miller

Department of Radiology and Imaging Sciences, Division of Radiobiology, University of Utah, Salt Lake City, UT 84112, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

R. Lor Randall

Department of Orthopaedics, University of Utah, Salt Lake City, UT 84112, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Neysi Anderson

Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT 84112, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Susan E. Waltz

Department of Cancer and Cell Biology, University of Cincinnati and Cincinnati Veterans Affairs Medical Center, Cincinnati, OH 45267, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Mark McHale

Aslan Pharmaceuticals, Singapore 089824, Singapore.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Alana L. Welm

Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT 84112, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
For correspondence: alana.welm@hci.utah.edu

Article
Figures & Data
Info & Metrics
eLetters
PDF

Log in to view Figures & Data

via AAAS login

AAAS login provides access to Science for AAAS members, and access to other journals in the Science family to users who have purchased individual subscriptions.

Become an AAAS Member
Activate your Account
Purchase Access to Other Journals in the Science Family
Account Help

As a service to the community, this article is available for free. Existing users log in.

Become a AAAS member
Account help

Log in through your institution

More options

Purchase digital access to this article

Download and print this article for your personal scholarly, research, and educational use.

Purchase this issue in print

Buy a single issue of Science for just $15 USD.

View Full Text

RON kinase: A target for treatment of cancer-induced bone destruction and osteoporosis

Log in to view Figures & Data

Log in through your institution

Log in through your institution

More options

Science Translational Medicine

Article Tools