Research ArticleAlzheimer’s Disease

Tau reduction prevents neuronal loss and reverses pathological tau deposition and seeding in mice with tauopathy

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Science Translational Medicine  25 Jan 2017:
Vol. 9, Issue 374, eaag0481
DOI: 10.1126/scitranslmed.aag0481

Article Information

vol. 9 no. 374

PubMed: 
Print ISSN: 
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History: 
  • Received for publication October 19, 2015
  • Resubmitted May 13, 2016
  • Accepted for publication November 17, 2016
  • .

Author Information

  1. Sarah L. DeVos1,
  2. Rebecca L. Miller1,*,
  3. Kathleen M. Schoch1,*,
  4. Brandon B. Holmes1,
  5. Carey S. Kebodeaux1,
  6. Amy J. Wegener1,
  7. Guo Chen1,
  8. Tao Shen1,
  9. Hien Tran2,
  10. Brandon Nichols2,
  11. Tom A. Zanardi2,
  12. Holly B. Kordasiewicz2,
  13. Eric E. Swayze2,
  14. C. Frank Bennett2,
  15. Marc I. Diamond3 and
  16. Timothy M. Miller1,
  1. 1Department of Neurology, Hope Center for Neurological Disorders, Washington University in St. Louis, St. Louis, MO 63110, USA.
  2. 2Ionis Pharmaceuticals, Carlsbad, CA 90201, USA.
  3. 3Center for Alzheimer’s and Neurodegenerative Diseases, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
  1. Corresponding author. Email: miller.t{at}wustl.edu
    • * These authors contributed equally to this work.

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