25 January 2017
Vol 9, Issue 374

About The Cover

Cover image expansion

ONLINE COVER Hypoxia and the Heart-Brain Connection. This image shows astrocytes (red) and neuroblasts (green) within the subventricular zone (SVZ) in a neonatal piglet brain. Morton et al. show that chronic oxygen deficiency (hypoxia) reduces the number of neural stem/progenitor cells within the SVZ in neonatal piglet brains, which limits postnatal cortical development. These findings in hypoxic piglet brains are reminiscent of those in postmortem brain tissue samples from human infants with congenital heart disease. The authors propose that targeting the neural stem/progenitor cells within the subventricular zone may improve cortical development in children with congenital heart disease. [CREDIT: PAUL D. MORTON/CHILDREN'S NATIONAL HEALTH SYSTEM]