Editors' ChoiceDiabetes

ERAD-icating mutant insulin promotes functional insulin secretion

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Science Translational Medicine  18 Jan 2017:
Vol. 9, Issue 373, eaal4995
DOI: 10.1126/scitranslmed.aal4995


Overexpression of a chaperone protein liberates functional insulin from a misfolded mutant partner to improve insulin secretion.

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