Tyrosine kinase blocking collagen IV–derived peptide suppresses ocular neovascularization and vascular leakage

Raquel Lima e Silva; Yogita Kanan; Adam C. Mirando; Jayoung Kim; Ron B. Shmueli; Valeria E. Lorenc; Seth D. Fortmann; Jason Sciamanna; Niranjan B. Pandey; Jordan J. Green; Aleksander S. Popel; Peter A. Campochiaro

doi:10.1126/scitranslmed.aai8030

Research ArticleRetinopathy

Tyrosine kinase blocking collagen IV–derived peptide suppresses ocular neovascularization and vascular leakage

Raquel Lima e Silva¹,²,*,
Yogita Kanan¹,²,*,
Adam C. Mirando³,
Jayoung Kim³,⁴,
Ron B. Shmueli³,⁴,
Valeria E. Lorenc¹,²,
Seth D. Fortmann¹,²,
Jason Sciamanna¹,²,
Niranjan B. Pandey³,⁵,
Jordan J. Green¹,³,⁴,⁶,
Aleksander S. Popel³ and
Peter A. Campochiaro¹,²,†

¹Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
²Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
³Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
⁴Translational Tissue Engineering Center, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
⁵AsclepiX Therapeutics, LLC, Baltimore, MD 21211, USA.
⁶Institute for Nanobiotechnology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

↵†Corresponding author. Email: pcampo{at}jhmi.edu

↵* These authors contributed equally to this work.

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Science Translational Medicine 18 Jan 2017:
Vol. 9, Issue 373, eaai8030
DOI: 10.1126/scitranslmed.aai8030

Raquel Lima e Silva

1Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

2Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

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Yogita Kanan

1Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

2Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

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Adam C. Mirando

3Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

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Jayoung Kim

3Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

4Translational Tissue Engineering Center, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

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Ron B. Shmueli

3Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

4Translational Tissue Engineering Center, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

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Valeria E. Lorenc

1Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

2Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

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Seth D. Fortmann

1Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

2Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

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Jason Sciamanna

1Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

2Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

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Niranjan B. Pandey

3Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

5AsclepiX Therapeutics, LLC, Baltimore, MD 21211, USA.

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Jordan J. Green

1Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

3Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

4Translational Tissue Engineering Center, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

6Institute for Nanobiotechnology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

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Aleksander S. Popel

3Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

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Peter A. Campochiaro

1Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

2Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

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For correspondence: pcampo@jhmi.edu

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An integrin-binding peptide derived from collagen IV prevents ligand-induced activation of multiple tyrosine kinase receptors and strongly suppresses ocular neovascularization and vascular leakage.

Tyrosine kinase blocking collagen IV–derived peptide suppresses ocular neovascularization and vascular leakage

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