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Research ArticleRetinopathy
Tyrosine kinase blocking collagen IV–derived peptide suppresses ocular neovascularization and vascular leakage
- Raquel Lima e Silva1,2,*,
- Yogita Kanan1,2,*,
- Adam C. Mirando3,
- Jayoung Kim3,4,
- Ron B. Shmueli3,4,
- Valeria E. Lorenc1,2,
- Seth D. Fortmann1,2,
- Jason Sciamanna1,2,
- Niranjan B. Pandey3,5,
- Jordan J. Green1,3,4,6,
- Aleksander S. Popel3 and
- Peter A. Campochiaro1,2,†
- 1Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
- 2Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
- 3Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
- 4Translational Tissue Engineering Center, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
- 5AsclepiX Therapeutics, LLC, Baltimore, MD 21211, USA.
- 6Institute for Nanobiotechnology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
- ↵†Corresponding author. Email: pcampo{at}jhmi.edu
↵* These authors contributed equally to this work.
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Science Translational Medicine 18 Jan 2017:
Vol. 9, Issue 373, eaai8030
DOI: 10.1126/scitranslmed.aai8030
Vol. 9, Issue 373, eaai8030
DOI: 10.1126/scitranslmed.aai8030
Raquel Lima e Silva
1Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
2Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Yogita Kanan
1Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
2Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Adam C. Mirando
3Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Jayoung Kim
3Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
4Translational Tissue Engineering Center, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Ron B. Shmueli
3Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
4Translational Tissue Engineering Center, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Valeria E. Lorenc
1Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
2Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Seth D. Fortmann
1Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
2Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Jason Sciamanna
1Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
2Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Niranjan B. Pandey
3Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
5AsclepiX Therapeutics, LLC, Baltimore, MD 21211, USA.
Jordan J. Green
1Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
3Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
4Translational Tissue Engineering Center, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
6Institute for Nanobiotechnology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Aleksander S. Popel
3Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Peter A. Campochiaro
1Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
2Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
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