Contents
18 January 2017
Vol 9, Issue 373
Vol 9, Issue 373
Research Articles
- Reporter gene imaging of targeted T cell immunotherapy in recurrent glioma
PET gene reporter imaging can be used to monitor the trafficking of therapeutic cytotoxic T cells in glioma patients.
- Coexistence of potent HIV-1 broadly neutralizing antibodies and antibody-sensitive viruses in a viremic controller
Three new potent neutralizing antibodies neutralize autologous HIV-1 strains and contribute to viral control in an HIV-1 controller.
- Soft robotic sleeve supports heart function
A soft robotic sleeve modeled on the structure of the human heart assists cardiovascular function in an ex vivo and in vivo porcine model of heart failure.
- Follicular CD8 T cells accumulate in HIV infection and can kill infected cells in vitro via bispecific antibodies
LN inflammation in chronic HIV is associated with accumulation of follicular CD8 T cells that could be redirected to kill infected cells.
- Tyrosine kinase blocking collagen IV–derived peptide suppresses ocular neovascularization and vascular leakage
An integrin-binding peptide derived from collagen IV prevents ligand-induced activation of multiple tyrosine kinase receptors and strongly suppresses ocular neovascularization and vascular leakage.
Editors Choice
- Good to the last “emulsified” drop
Nanoliter scale droplets sealed and encapsulated in solid PEFE polymer shells are combined with graphical coding to advance droplet microfluidics.
- A sterile animal model for neuroinflammation?
MRI-guided pulsed focused ultrasound combined with systemic infusion of contrast agent microbubbles induces local neuroinflammation in the rat.
- ERAD-icating mutant insulin promotes functional insulin secretion
Overexpression of a chaperone protein liberates functional insulin from a misfolded mutant partner to improve insulin secretion.
- CAR T cells engage in anticancer martial arts
A clever redesign of the chimeric antigen receptor T cell concept turns a cancer-mediated immunosuppressive cytokine into a growth signal.
About The Cover
ONLINE COVER Artificial Muscles Assist the Heart. This computed tomography image shows a ventricular assist device surrounding an isolated pig heart (Roche et al.). The device, composed of layered pneumatic artificial muscle actuators in a soft polymer material, increased ventricular ejection volume in vitro and cardiac output in vivo during cardiac arrest in pigs. The artificial muscles within the sleeve-like soft robotic device could twist and compress, providing ventricle-specific assistance that mimics the motion of the natural heart. [CREDIT: ROCHE ET AL./SCIENCE TRANSLATIONAL MEDICINE]