11 January 2017
Vol 9, Issue 372

About The Cover

Cover image expansion

ONLINE COVER Lighting a Path to GVHD Prevention. Pictured here is the Aurora borealis, a natural light display visible near the North Pole. Targeting Aurora kinase A and Janus kinase 2 with a small molecule inhibitor resulted in blunting of donor T cell activation after stem cell transplantation in mice with a human immune system (Betts et al.). Inactivating these kinases drove human T cells toward a regulatory phenotype and prevented graft-versus-host disease in the humanized mice. Importantly, T cells treated with the inhibitor were still able to kill tumor cells, suggesting that patients receiving this treatment could still mount a crucial antileukemia response if a relapse occurred. [CREDIT: KEVIN SCHAFER/ALAMY STOCK PHOTO]