Contents
11 January 2017
Vol 9, Issue 372
Vol 9, Issue 372
Perspective
- Disruptive reproductive technologies
In vitro gametogenesis raises new possibilities for reproductive and regenerative medicine as well as vexing policy challenges.
Research Articles
- Targeting Aurora kinase A and JAK2 prevents GVHD while maintaining Treg and antitumor CTL function
Inhibiting Aurora kinase A and JAK2 signal transduction pathways permits the differentiation of potent regulatory T cells while neutralizing alloreactive T cells and preventing graft-versus-host disease without impairing antitumor responses.
- Post hoc assessment of the immunogenicity of bioengineered factor VIIa demonstrates the use of preclinical tools
A computational and experimental strategy assesses the immunogenicity risk of bioengineered therapeutic proteins.
- A PTK7-targeted antibody-drug conjugate reduces tumor-initiating cells and induces sustained tumor regressions
PTK7 is a tumor-initiating cell antigen, which can be targeted with an antibody-drug conjugate to confer sustained tumor regressions.
- Pharmacological rescue of diabetic skeletal stem cell niches
Local delivery of a missing growth factor to the skeletal stem cell niche restores bone healing in diabetic mice.
- CRISPR-Cas9 gene repair of hematopoietic stem cells from patients with X-linked chronic granulomatous disease
CRISPR-mediated gene repair of hematopoietic stem cells from patients with X-linked chronic granulomatous disease resulted in functional human leukocytes in mice after transplantation.
Editors Choice
- Endomicroscope sheds light on cervical tissue
A pilot study of a handheld fluorescence endomicroscope demonstrates both in vivo imaging and differentiation of normal from precancerous cervical tissue.
- Tune into the rhythm of your bugs
Diurnal changes in gut microbiota localization and function alter host physiology through circadian epigenetic and transcriptional changes.
- A weighty problem
Altered dopamine signaling in obesity might decrease physical activity without contributing to weight gain.
- DAMPening the effects of trauma-induced inflammation
Amine-containing polymers immobilized on mesh and placed at trauma sites scavenge biomolecules that initiate a damaging immune response.
About The Cover
ONLINE COVER Lighting a Path to GVHD Prevention. Pictured here is the Aurora borealis, a natural light display visible near the North Pole. Targeting Aurora kinase A and Janus kinase 2 with a small molecule inhibitor resulted in blunting of donor T cell activation after stem cell transplantation in mice with a human immune system (Betts et al.). Inactivating these kinases drove human T cells toward a regulatory phenotype and prevented graft-versus-host disease in the humanized mice. Importantly, T cells treated with the inhibitor were still able to kill tumor cells, suggesting that patients receiving this treatment could still mount a crucial antileukemia response if a relapse occurred. [CREDIT: KEVIN SCHAFER/ALAMY STOCK PHOTO]
