Research ArticleWound Healing

A bioengineered living cell construct activates an acute wound healing response in venous leg ulcers

See allHide authors and affiliations

Science Translational Medicine  04 Jan 2017:
Vol. 9, Issue 371, eaaf8611
DOI: 10.1126/scitranslmed.aaf8611

You are currently viewing the editor's summary.

View Full Text

Log in to view the full text

Log in through your institution

Log in through your institution

Activating healing in chronic wounds

Effective therapies for chronic venous leg ulcers (VLUs) remain elusive, in part, because of the incomplete understanding of the pathophysiology of nonhealing wounds. Stone et al. conducted a postmarket clinical trial using transcriptomics to understand the mechanisms of action of an FDA-approved bilayered living cellular construct (BLCC) in nonhealing VLUs. After 1 week of BLCC treatment in addition to standard of care compression therapy, nonhealing VLUs showed changes in inflammation and gene expression characteristic of acutely healing wounds. This study provides mechanistic insight into how the acute healing process can be activated by a cell therapy in chronic nonhealing wounds.

View Full Text

Stay Connected to Science Translational Medicine