Research ArticleCOAGULATION

Targeted clinical control of trauma patient coagulation through a thrombin dynamics model

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Science Translational Medicine  04 Jan 2017:
Vol. 9, Issue 371, eaaf5045
DOI: 10.1126/scitranslmed.aaf5045

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The key to resuscitation is in the blood

In the setting of severe trauma, some patients develop acute traumatic coagulopathy, impaired coagulation that can occur in response to shock. For patients who are already bleeding and then develop coagulopathy, there is no time to carefully perform laboratory analysis, and blood products are usually transfused according to standardized protocols. Because these protocols are not tailored to individual patients or injuries, this can result in insufficient or excessive blood product transfusions, which contribute to the high risk of mortality. Using dynamic modeling, Menezes et al. demonstrated a method for calculating each patient’s transfusion requirements using only laboratory values that can be easily and quickly obtained in the emergency setting, which should allow for individually tailored resuscitation.

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