04 January 2017
Vol 9, Issue 371

About The Cover

Cover image expansion

ONLINE COVER A Triple Knockout Punch For Malaria. Sporozoites of the malaria parasite (pictured), injected by the mosquito vector into the human bloodstream, migrate to the liver where they begin the parasite's life cycle in the human host. Sporozoites attenuated by radiation are under investigation for development of a whole parasite vaccine. Kublin et al. now attenuate sporozoites of Plasmodium falciparum by knocking out three key genes that prevent the sporozoites from developing inside host liver cells. They test their vaccine in 10 healthy volunteers and demonstrate a strong immune response and no breakthrough infection, paving the way for clinical testing of a whole live-attenuated sporozoite vaccine. [CREDIT: LONDON SCHOOL OF HYGIENE & TROPICAL MEDICINE/SCIENCE SOURCE]