Contents
04 January 2017
Vol 9, Issue 371
Vol 9, Issue 371
Editorial
- The study is open: Participants are now recruiting investigators
Two U.S. national initiatives have stated emphatically that people will be partners, not patients, in clinical research.
Research Articles
- Optimized temporal pattern of brain stimulation designed by computational evolution
Computational evolution produces an improved pattern of brain stimulation to treat Parkinson’s disease in animals and patients.
- Targeted clinical control of trauma patient coagulation through a thrombin dynamics model
A control-oriented dynamical system model of trauma coagulation helps tailor the resuscitation of severely injured patients.
- A bioengineered living cell construct activates an acute wound healing response in venous leg ulcers
A bioengineered bilayered living cellular construct promotes ulcer healing by modulating inflammation, stimulating wound edge keratinocytes, and attenuating Wnt/β-catenin signaling to activate an acute wound response.
- Complete attenuation of genetically engineered Plasmodium falciparum sporozoites in human subjects
A genetically attenuated Plasmodium falciparum strain called Pf GAP3KO is completely attenuated, safe, and immunogenic in adults.
- Blockade of protease-activated receptor-4 (PAR4) provides robust antithrombotic activity with low bleeding
PAR4 inhibition with a reversible small-molecule antagonist is a promising antiplatelet therapy.
Editors' Choice
- Unleashing the wrath of Ras
Combined epigenetic silencing of two tumor suppressors promotes metastasis in luminal B breast cancers.
- Fear memory erasure through neuronal transplantation
Transplant of immature inhibitory neurons can erase fear memories in adult mice.
- Interfering with HIV therapy
Type 1 interferon signaling promotes HIV persistence even during combined antiretroviral therapy.
- A case of mistaken identity
Genuine disseminated tumor cells arise late in the life of a tumor and resemble clones from primary breast cancers or their metastases.
About The Cover
ONLINE COVER A Triple Knockout Punch For Malaria. Sporozoites of the malaria parasite (pictured), injected by the mosquito vector into the human bloodstream, migrate to the liver where they begin the parasite's life cycle in the human host. Sporozoites attenuated by radiation are under investigation for development of a whole parasite vaccine. Kublin et al. now attenuate sporozoites of Plasmodium falciparum by knocking out three key genes that prevent the sporozoites from developing inside host liver cells. They test their vaccine in 10 healthy volunteers and demonstrate a strong immune response and no breakthrough infection, paving the way for clinical testing of a whole live-attenuated sporozoite vaccine. [CREDIT: LONDON SCHOOL OF HYGIENE & TROPICAL MEDICINE/SCIENCE SOURCE]