Research ArticlePRION DISEASES

Detection of prions in the plasma of presymptomatic and symptomatic patients with variant Creutzfeldt-Jakob disease

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Science Translational Medicine  21 Dec 2016:
Vol. 8, Issue 370, pp. 370ra182
DOI: 10.1126/scitranslmed.aag1257

Article Information

vol. 8 no. 370 370ra182

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History: 
  • Received for publication October 10, 2015
  • Resubmitted May 12, 2016
  • Accepted for publication November 17, 2016
  • .

Author Information

  1. Daisy Bougard1,*,
  2. Jean-Philippe Brandel2,3,4,
  3. Maxime Bélondrade1,
  4. Vincent Béringue5,
  5. Christiane Segarra1,
  6. Hervé Fleury6,
  7. Jean-Louis Laplanche4,7,
  8. Charly Mayran1,
  9. Simon Nicot1,
  10. Alison Green8,
  11. Arlette Welaratne3,
  12. David Narbey9,
  13. Chantal Fournier-Wirth1,
  14. Richard Knight8,
  15. Robert Will8,
  16. Pierre Tiberghien9,10,
  17. Stéphane Haïk2,3,4 and
  18. Joliette Coste1,9,*
  1. 1Etablissement Français du Sang, INSERM, Université de Montpellier, UMR 1058, TransDiag, F-34184 Montpellier, France.
  2. 2Sorbonne Universités, UPMC Univ Paris 06, INSERM, CNRS, Institut du Cerveau et de la Moelle épinière (ICM)–Hôpital Pitié-Salpêtrière, F-75013 Paris, France.
  3. 3Assistance publique–Hôpitaux de Paris, Cellule Nationale de Référence des Maladies de Creutzfeldt-Jakob, Groupe Hospitalier Pitié-Salpêtrière, F-75013 Paris, France.
  4. 4Centre National de Référence des Agents Transmissibles Non Conventionnels, F-75013 Paris, France.
  5. 5Institut National de la Recherche Agronomique, Université Paris-Saclay, Virologie Immunologie Moléculaire, F-78350 Jouy-en-Josas, France.
  6. 6Laboratoire de Virologie, Hôpital Pellegrin, F-33076 Bordeaux, France.
  7. 7Service de Biochimie et Biologie Moléculaire, Hôpital Lariboisière, F-75010 Paris, France.
  8. 8National Creutzfeldt-Jakob Disease Research and Surveillance Unit, Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh EH4 2XU, U.K.
  9. 9Etablissement Français du Sang, F-93218 La Plaine Saint Denis, France.
  10. 10INSERM, Etablissement Français du Sang, Université de Franche-Comté, UMR 1098, F-25020 Besançon, France.
  1. *Corresponding author. Email: joliette.coste{at}efs.sante.fr (J.C.); daisy.bougard{at}efs.sante.fr (D.B.)

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