Research ArticleNeurodegenerative Disease

Adenylyl cyclase activating polypeptide reduces phosphorylation and toxicity of the polyglutamine-expanded androgen receptor in spinobulbar muscular atrophy

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Science Translational Medicine  21 Dec 2016:
Vol. 8, Issue 370, pp. 370ra181
DOI: 10.1126/scitranslmed.aaf9526

Article Information

vol. 8 no. 370 370ra181

PubMed: 
Print ISSN: 
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History: 
  • Received for publication October 27, 2015
  • Resubmitted May 2, 2016
  • Accepted for publication December 1, 2016
  • .

Author Information

  1. Maria Josè Polanco1,2,*,
  2. Sara Parodi2,3,*,
  3. Diana Piol1,
  4. Conor Stack3,
  5. Mathilde Chivet1,
  6. Andrea Contestabile2,
  7. Helen C. Miranda4,5,
  8. Patricia M.-J. Lievens6,
  9. Stefano Espinoza2,
  10. Tobias Jochum7,
  11. Anna Rocchi2,
  12. Christopher Grunseich3,
  13. Raul R. Gainetdinov8,9,
  14. Andrew C. B. Cato10,
  15. Andrew P. Lieberman11,
  16. Albert R. La Spada4,5,
  17. Fabio Sambataro12,
  18. Kenneth H. Fischbeck3,
  19. Illana Gozes13 and
  20. Maria Pennuto1,2,
  1. 1Dulbecco Telethon Institute, Centre for Integrative Biology, University of Trento, 38123 Trento, Italy.
  2. 2Department of Neuroscience and Brain Technologies, Istituto Italiano di Tecnologia, 16163 Genoa, Italy.
  3. 3Neurogenetics Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA.
  4. 4Departments of Cellular and Molecular Medicine, Pediatrics, and Neurosciences, and Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92093, USA.
  5. 5Institute for Genomic Medicine, University of California, San Diego, La Jolla, CA 92093, USA.
  6. 6Department of Neurosciences, Biomedicine and Movement Sciences, Section of Biology and Genetics, University of Verona, 37134 Verona, Italy.
  7. 7Laboratory for Applications of Synchrotron Radiation, Karlsruhe Institute of Technology, and abcr GmbH, Karlsruhe, Germany.
  8. 8Institute of Translational Biomedicine, St. Petersburg State University, 199034 St. Petersburg, Russia.
  9. 9Skolkovo Institute of Science and Technology, Skolkovo, 143025 Moscow, Russia.
  10. 10Institute of Toxicology and Genetics, Karlsruhe Institute of Technology, 76344 Eggenstein-Leopoldshafen, Germany.
  11. 11Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
  12. 12Department of Experimental and Clinical Medical Sciences (DISM), University of Udine, 33100 Udine, Italy.
  13. 13Department of Human Molecular Genetics and Biochemistry, Sackler Faculty of Medicine, Sagol School of Neuroscience and Adams Super Center for Brain Studies, Tel Aviv University, Tel Aviv 69978, Israel.
  1. Corresponding author. Email: mpennuto{at}dti.telethon.it
    • * These authors contributed equally to this work.

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