Research ArticleZIKA VIRUS

Molecular determinants of human neutralizing antibodies isolated from a patient infected with Zika virus

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Science Translational Medicine  14 Dec 2016:
Vol. 8, Issue 369, pp. 369ra179
DOI: 10.1126/scitranslmed.aai8336

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Stopping Zika virus in its tracks

Zika virus is a global concern because of its association with fetal microcephaly and neurological complications, and there are no approved countermeasures. In new work, Wang et al. isolated 13 antibodies from a patient infected with Zika virus, two of which (Z3L1 and Z23) showed potent neutralizing activity without cross-reactivity to dengue virus strains 1 to 4. Moreover, the Z3L1 and Z23 antibodies conferred postexposure protection against Zika virus in a murine model. Structural studies indicated that the antibodies bound to different viral epitopes, suggesting that these antibodies could be used as a therapeutic cocktail.

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