Research ArticleAutoimmunity

Aggregatibacter actinomycetemcomitans–induced hypercitrullination links periodontal infection to autoimmunity in rheumatoid arthritis

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Science Translational Medicine  14 Dec 2016:
Vol. 8, Issue 369, pp. 369ra176
DOI: 10.1126/scitranslmed.aaj1921

Article Information

vol. 8 no. 369 369ra176

PubMed: 
Print ISSN: 
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History: 
  • Received for publication March 28, 2016
  • Resubmitted September 9, 2016
  • Accepted for publication November 9, 2016
  • .

Author Information

  1. Maximilian F. Konig1,*,
  2. Loreto Abusleme2,
  3. Jesper Reinholdt3,
  4. Robert J. Palmer2,
  5. Ricardo P. Teles4,5,
  6. Kevon Sampson1,
  7. Antony Rosen1,
  8. Peter A. Nigrovic6,7,
  9. Jeremy Sokolove8,
  10. Jon T. Giles9,
  11. Niki M. Moutsopoulos2 and
  12. Felipe Andrade1,
  1. 1Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA.
  2. 2National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA.
  3. 3Department of Biomedicine, Aarhus University, 8000 Aarhus C, Denmark.
  4. 4Department of Periodontology, School of Dentistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
  5. 5Department of Applied Oral Sciences, Forsyth Institute, Cambridge, MA 02142, USA.
  6. 6Division of Rheumatology, Immunology, and Allergy, Brigham and Women’s Hospital, Boston, MA 02115, USA.
  7. 7Division of Immunology, Boston Children’s Hospital, Boston, MA 02115, USA.
  8. 8Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA 94305, USA.
  9. 9Division of Rheumatology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.
  1. Corresponding author. Email: andrade{at}jhmi.edu
  • * Present address: Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.

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