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Research ArticleCancer
PIK3CA mutations enable targeting of a breast tumor dependency through mTOR-mediated MCL-1 translation
- Grace R. Anderson1,
- Suzanne E. Wardell1,
- Merve Cakir1,2,
- Lorin Crawford1,3,
- Jim C. Leeds1,
- Daniel P. Nussbaum1,4,
- Pallavi S. Shankar1,
- Ryan S. Soderquist1,
- Elizabeth M. Stein1,
- Jennifer P. Tingley1,
- Peter S. Winter1,5,
- Elizabeth K. Zieser-Misenheimer1,
- Holly M. Alley1,
- Alexander Yllanes1,
- Victoria Haney1,
- Kimberly L. Blackwell6,
- Shannon J. McCall7,
- Donald P. McDonnell1 and
- Kris C. Wood1,*
- 1Department of Pharmacology and Cancer Biology, Duke University, Durham, NC 27710, USA.
- 2Program in Computational Biology and Bioinformatics, Duke University, Durham, NC 27708, USA.
- 3Department of Statistical Science, Duke University, Durham, NC 27708, USA.
- 4Department of Surgery, Duke University, Durham, NC 27710, USA.
- 5Program in Genetics and Genomics, Duke University, Durham, NC 27710, USA.
- 6Department of Medicine/Oncology, Duke University, Durham, NC 27710, USA.
- 7Department of Pathology, Duke University, Durham, NC 27710, USA.
- ↵*Corresponding author. Email: kris.wood{at}duke.edu
See allHide authors and affiliations
Science Translational Medicine 14 Dec 2016:
Vol. 8, Issue 369, pp. 369ra175
DOI: 10.1126/scitranslmed.aae0348
Vol. 8, Issue 369, pp. 369ra175
DOI: 10.1126/scitranslmed.aae0348
Grace R. Anderson
1Department of Pharmacology and Cancer Biology, Duke University, Durham, NC 27710, USA.
Suzanne E. Wardell
1Department of Pharmacology and Cancer Biology, Duke University, Durham, NC 27710, USA.
Merve Cakir
1Department of Pharmacology and Cancer Biology, Duke University, Durham, NC 27710, USA.
2Program in Computational Biology and Bioinformatics, Duke University, Durham, NC 27708, USA.
Lorin Crawford
1Department of Pharmacology and Cancer Biology, Duke University, Durham, NC 27710, USA.
3Department of Statistical Science, Duke University, Durham, NC 27708, USA.
Jim C. Leeds
1Department of Pharmacology and Cancer Biology, Duke University, Durham, NC 27710, USA.
Daniel P. Nussbaum
1Department of Pharmacology and Cancer Biology, Duke University, Durham, NC 27710, USA.
4Department of Surgery, Duke University, Durham, NC 27710, USA.
Pallavi S. Shankar
1Department of Pharmacology and Cancer Biology, Duke University, Durham, NC 27710, USA.
Ryan S. Soderquist
1Department of Pharmacology and Cancer Biology, Duke University, Durham, NC 27710, USA.
Elizabeth M. Stein
1Department of Pharmacology and Cancer Biology, Duke University, Durham, NC 27710, USA.
Jennifer P. Tingley
1Department of Pharmacology and Cancer Biology, Duke University, Durham, NC 27710, USA.
Peter S. Winter
1Department of Pharmacology and Cancer Biology, Duke University, Durham, NC 27710, USA.
5Program in Genetics and Genomics, Duke University, Durham, NC 27710, USA.
Elizabeth K. Zieser-Misenheimer
1Department of Pharmacology and Cancer Biology, Duke University, Durham, NC 27710, USA.
Holly M. Alley
1Department of Pharmacology and Cancer Biology, Duke University, Durham, NC 27710, USA.
Alexander Yllanes
1Department of Pharmacology and Cancer Biology, Duke University, Durham, NC 27710, USA.
Victoria Haney
1Department of Pharmacology and Cancer Biology, Duke University, Durham, NC 27710, USA.
Kimberly L. Blackwell
6Department of Medicine/Oncology, Duke University, Durham, NC 27710, USA.
Shannon J. McCall
7Department of Pathology, Duke University, Durham, NC 27710, USA.
Donald P. McDonnell
1Department of Pharmacology and Cancer Biology, Duke University, Durham, NC 27710, USA.
Kris C. Wood
1Department of Pharmacology and Cancer Biology, Duke University, Durham, NC 27710, USA.
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