Contents
14 December 2016
Vol 8, Issue 369
Vol 8, Issue 369
Contents
Research Articles
- PIK3CA mutations enable targeting of a breast tumor dependency through mTOR-mediated MCL-1 translation
Inhibitors of BCL-XL, combined with inhibition of the mTOR/4E-BP axis, drive regressions of PIK3CA mutant breast tumors.
- Aggregatibacter actinomycetemcomitans–induced hypercitrullination links periodontal infection to autoimmunity in rheumatoid arthritis
Aggregatibacter actinomycetemcomitans generates citrullinated autoantigens involved in rheumatoid arthritis through its pore-forming toxin leukotoxin A.
- The protein phosphatase 2A regulatory subunit PR70 is a gonosomal melanoma tumor suppressor gene
A protein phosphatase regulator modulates tumorigenicity in a dose- and X chromosome–dependent manner.
- Early changes in CSF sTREM2 in dominantly inherited Alzheimer’s disease occur after amyloid deposition and neuronal injury
CSF sTREM2 increases in early stages of autosomal dominant Alzheimer’s disease, but the increase occurs after changes in Aβ and tau.
- Molecular determinants of human neutralizing antibodies isolated from a patient infected with Zika virus
Zika virus–specific antibodies isolated from a single infected patient show postexposure protection in mice and reveal targets for therapy.
Editors' Choice
- Eating to boost gut microbial diversity
Limiting dietary nitrogen alters gut microbial diversity to promote healthy aging.
- Screen and you shall find
Newborn screening for a rare immunodeficiency leads to treatment and a greater understanding of a gene’s diverse functions.
- Alzheimer’s medicine: β-Amyloid takes a siP
Disrupting the binding of β-amyloid oligomers to EphB2 receptor using a small interfering peptide is neuroprotective in a mouse model of Alzheimer’s disease.
- A new lease on half-life
A polymer-exenatide conjugate lowers blood glucose for 120 hours without inducing the antigenicity caused by PEGylated protein drugs.
Erratum
About The Cover
ONLINE COVER Stopping Zika in Its Tracks. Shown is a molecular model of the Zika virus, a mosquito-borne pathogen that is associated with microcephaly in babies whose mothers were infected during pregnancy. Wang et al. isolated monoclonal antibodies from the blood of a patient infected with the Zika virus. They showed that two of these antibodies directed against the viral Env protein had neutralizing capabilities, blocking Zika virus replication in vitro and protecting mice from viral challenge in vivo. This study provides insights into the potential design of vaccines against Zika virus. [CREDIT: EVAN OTO/SCIENCE SOURCE]