Research ArticleCancer

AZD3759, a BBB-penetrating EGFR inhibitor for the treatment of EGFR mutant NSCLC with CNS metastases

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Science Translational Medicine  07 Dec 2016:
Vol. 8, Issue 368, pp. 368ra172
DOI: 10.1126/scitranslmed.aag0976

Article Information

vol. 8 no. 368 368ra172

PubMed: 
Print ISSN: 
Online ISSN: 
History: 
  • Received for publication May 9, 2016
  • Accepted for publication September 8, 2016
  • .

Author Information

  1. Zhenfan Yang1,
  2. Qiuli Guo1,
  3. Yingchun Wang1,
  4. Kan Chen1,
  5. Lin Zhang1,
  6. Ziqiang Cheng1,
  7. Yanping Xu1,
  8. Xiaolu Yin1,
  9. Yu Bai1,
  10. Sarit Rabbie2,
  11. Dong-Wan Kim3,
  12. Myung-Ju Ahn4,
  13. James Chih-Hsin Yang5 and
  14. Xiaolin Zhang1,*
  1. 1Asia Innovative Medicines, AstraZeneca, Shanghai 201203, China.
  2. 2Early Clinical Development, AstraZeneca, Cambridge, Hertz SG8 6EE, U.K.
  3. 3Department of Internal Medicine, Seoul National University Hospital, 101 Daehak-ro, Jongno-gu, Seoul 03080, South Korea.
  4. 4Department of Medicine, Sungkyunkwan University School of Medicine, Samsung Medical Center, Irwon-ro, Gangnam-gu, Seoul 135-710, South Korea.
  5. 5Department of Oncology, National Taiwan University Hospital and National Taiwan University Cancer Center, 7, Chung-Shan South Road, Taipei 10002, Taiwan, ROC.
  1. *Corresponding author. Email: xiaolin.zhang{at}astrazeneca.com

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