Contents

Contents

• Research Articles

  • Individualized vaccination of AML patients in remission is associated with induction of antileukemia immunity and prolonged remissions

    By Jacalyn Rosenblatt, Richard M. Stone, Lynne Uhl, Donna Neuberg, Robin Joyce, James D. Levine, Jon Arnason, Malgorzata McMasters, Katarina Luptakova, Salvia Jain, Jeffrey I. Zwicker, Ayad Hamdan, Vassiliki Boussiotis, David P. Steensma, Daniel J. DeAngelo, Ilene Galinsky, Poorvi Somaiya Dutt, Emma Logan, Mary Paty Bryant, Dina Stroopinsky, Lillian Werner, Kristen Palmer, Max Coll, Abigail Washington, Leandra Cole, Donald Kufe, David Avigan

    Science Translational Medicine07 Dec 2016 : 368ra171 Full AccessRestricted Access

    A personalized DC/AML fusion cell vaccine promotes the expansion of leukemia-specific T cells and prolonged remission in patients.

    • Editor's Summary
    • Abstract
    • Full Text
    • PDF
    • Supplementary Materials

  • AZD3759, a BBB-penetrating EGFR inhibitor for the treatment of EGFR mutant NSCLC with CNS metastases

    By Zhenfan Yang, Qiuli Guo, Yingchun Wang, Kan Chen, Lin Zhang, Ziqiang Cheng, Yanping Xu, Xiaolu Yin, Yu Bai, Sarit Rabbie, Dong-Wan Kim, Myung-Ju Ahn, James Chih-Hsin Yang, Xiaolin Zhang

    Science Translational Medicine07 Dec 2016 : 368ra172 Full AccessRestricted Access

    AZD3759 can penetrate the blood-brain barrier to treat EGFR mutant non–small-cell lung cancer with CNS metastases.

    • Editor's Summary
    • Abstract
    • Full Text
    • PDF
    • Supplementary Materials

  • Five-coordinate H64Q neuroglobin as a ligand-trap antidote for carbon monoxide poisoning

    By Ivan Azarov, Ling Wang, Jason J. Rose, Qinzi Xu, Xueyin N. Huang, Andrea Belanger, Ying Wang, Lanping Guo, Chen Liu, Kamil B. Ucer, Charles F. McTiernan, Christopher P. O’Donnell, Sruti Shiva, Jesús Tejero, Daniel B. Kim-Shapiro, Mark T. Gladwin

    Science Translational Medicine07 Dec 2016 : 368ra173 Full AccessRestricted Access

    A mutant five-coordinate neuroglobin with a very high carbon monoxide binding affinity acts as an antidote to bind and eliminate CO.

    • Editor's Summary
    • Abstract
    • Full Text
    • PDF
    • Supplementary Materials

  • Mitochondrial pyruvate carrier regulates autophagy, inflammation, and neurodegeneration in experimental models of Parkinson’s disease

    By Anamitra Ghosh, Trevor Tyson, Sonia George, Erin N. Hildebrandt, Jennifer A. Steiner, Zachary Madaj, Emily Schulz, Emily Machiela, William G. McDonald, Martha L. Escobar Galvis, Jeffrey H. Kordower, Jeremy M. Van Raamsdonk, Jerry R. Colca, Patrik Brundin

    Science Translational Medicine07 Dec 2016 : 368ra174 Full AccessRestricted Access

    Mitochondrial pyruvate carrier may be a therapeutic target in Parkinson’s disease.

    • Editor's Summary
    • Abstract
    • Full Text
    • PDF
    • Supplementary Materials

• Reports

  • Local changes in network structure contribute to late communication recovery after severe brain injury

    By Daniel J. Thengone, Henning U. Voss, Esteban A. Fridman, Nicholas D. Schiff

    Science Translational Medicine07 Dec 2016 : 368re5 Full AccessRestricted Access

    Longitudinal tracking of communication recovery after severe brain injury using imaging identifies use-dependent structural changes and functional correlates of late recovery.

    • Editor's Summary
    • Abstract
    • Full Text
    • PDF
    • Supplementary Materials

• Review

  • Emerging therapies for inherited retinal degeneration

    By Hendrik P. N. Scholl, Rupert W. Strauss, Mandeep S. Singh, Deniz Dalkara, Botond Roska, Serge Picaud, José-Alain Sahel

    Science Translational Medicine07 Dec 2016 : 368rv6 Full AccessRestricted Access

    This Review discusses current and emerging therapies for treating inherited retinal degeneration.

    • Abstract
    • Full Text
    • PDF

• Editors' Choice

  • Pitfalls of probiotics

    By Nirav R. Bhakta

    Science Translational Medicine07 Dec 2016 : 368ec194 Full AccessRestricted Access

    Specific bacterial species normally found in the human gut stimulate intestinal T_H17 responses and drive progression of systemic autoimmune disease in mice.

    • Full Text

  • β-amyloid can’t go with the flow

    By Brendan P. Lucey

    Science Translational Medicine07 Dec 2016 : 368ec195 Full AccessRestricted Access

    Reduced perivascular localization of aquaporin-4 channels is associated with Alzheimer’s disease pathology.

    • Full Text

  • LDL cholesterol hitches a ride

    By Katey J. Rayner

    Science Translational Medicine07 Dec 2016 : 368ec196 Full AccessRestricted Access

    A new lipid-binding protein transports low-density lipoprotein across the blood vessel endothelium and might promote atherosclerosis.

    • Full Text

  • An EXITS strategy for decreasing cancer risk in women

    By Kris C. Wood

    Science Translational Medicine07 Dec 2016 : 368ec197 Full AccessRestricted Access

    A large-scale analysis identifies putative tumor suppressor genes that protect women from cancer through escape from X-inactivation.

    • Full Text

• Erratum

  • Erratum for the Perspective: “Laying a trap to kill cancer cells: PARP inhibitors and their mechanisms of action” by Y. Pommier, M. J. O’Connor, J. de Bono

    Science Translational Medicine07 Dec 2016 : 368er7 Full AccessRestricted Access

    • Full Text