Contents
07 December 2016
Vol 8, Issue 368
Vol 8, Issue 368
Contents
Research Articles
- Individualized vaccination of AML patients in remission is associated with induction of antileukemia immunity and prolonged remissions
A personalized DC/AML fusion cell vaccine promotes the expansion of leukemia-specific T cells and prolonged remission in patients.
- AZD3759, a BBB-penetrating EGFR inhibitor for the treatment of EGFR mutant NSCLC with CNS metastases
AZD3759 can penetrate the blood-brain barrier to treat EGFR mutant non–small-cell lung cancer with CNS metastases.
- Five-coordinate H64Q neuroglobin as a ligand-trap antidote for carbon monoxide poisoning
A mutant five-coordinate neuroglobin with a very high carbon monoxide binding affinity acts as an antidote to bind and eliminate CO.
- Mitochondrial pyruvate carrier regulates autophagy, inflammation, and neurodegeneration in experimental models of Parkinson’s disease
Mitochondrial pyruvate carrier may be a therapeutic target in Parkinson’s disease.
Reports
- Local changes in network structure contribute to late communication recovery after severe brain injury
Longitudinal tracking of communication recovery after severe brain injury using imaging identifies use-dependent structural changes and functional correlates of late recovery.
Review
- Emerging therapies for inherited retinal degeneration
This Review discusses current and emerging therapies for treating inherited retinal degeneration.
Editors' Choice
- Pitfalls of probiotics
Specific bacterial species normally found in the human gut stimulate intestinal TH17 responses and drive progression of systemic autoimmune disease in mice.
- β-amyloid can’t go with the flow
Reduced perivascular localization of aquaporin-4 channels is associated with Alzheimer’s disease pathology.
- LDL cholesterol hitches a ride
A new lipid-binding protein transports low-density lipoprotein across the blood vessel endothelium and might promote atherosclerosis.
- An EXITS strategy for decreasing cancer risk in women
A large-scale analysis identifies putative tumor suppressor genes that protect women from cancer through escape from X-inactivation.
Erratum
About The Cover
ONLINE COVER A Deadly Dipole. Carbon monoxide—triple-bonded oxygen and carbon—is produced by incomplete combustion. A dangerous poison, carbon monoxide binds to hemoglobin, blocking its life-sustaining ability to carry oxygen. In this issue, Azarov et al. report the development of an antidote for this lethal gas. [CREDIT: C. BICKEL/G. GRULLÓN/SCIENCE TRANSLATIONAL MEDICINE]
