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Internalization of secreted antigen–targeted antibodies by the neonatal Fc receptor for precision imaging of the androgen receptor axis

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Science Translational Medicine  30 Nov 2016:
Vol. 8, Issue 367, pp. 367ra167
DOI: 10.1126/scitranslmed.aaf2335

Article Information

vol. 8 no. 367 367ra167

PubMed: 
Print ISSN: 
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History: 
  • Received for publication January 12, 2016
  • Resubmitted July 14, 2016
  • Accepted for publication September 13, 2016

Author Information

  1. Daniel L. J. Thorek1,2,
  2. Philip A. Watson3,*,
  3. Sang-Gyu Lee2,*,
  4. Anson T. Ku2,
  5. Stylianos Bournazos4,
  6. Katharina Braun5,
  7. Kwanghee Kim6,
  8. Kjell Sjöström7,
  9. Michael G. Doran2,
  10. Urpo Lamminmäki8,
  11. Elmer Santos2,
  12. Darren Veach2,9,
  13. Mesruh Turkekul10,
  14. Emily Casey11,
  15. Jason S. Lewis11,12,
  16. Diane S. Abou1,
  17. Marise R. H. van Voss1,13,
  18. Peter T. Scardino6,14,
  19. Sven-Erik Strand15,
  20. Mary L. Alpaugh16,
  21. Howard I. Scher17,18,
  22. Hans Lilja6,17,19,20,21,,
  23. Steven M. Larson2,9, and
  24. David Ulmert6,11,22,
  1. 1Division of Nuclear Medicine and Molecular Imaging, Department of Radiology and Radiological Science, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.
  2. 2Nuclear Medicine Service, Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
  3. 3Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
  4. 4Leonard Wagner Laboratory of Molecular Genetics and Immunology, Rockefeller University, New York, NY 10065, USA.
  5. 5Department of Urology, University Hospital of the Ruhr-University of Bochum, Marien Hospital Herne, Herne, Germany.
  6. 6Urology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
  7. 7Innovagen AB, Lund, Sweden.
  8. 8Department of Biochemistry, University of Turku, Turku, Finland.
  9. 9Department of Radiology, Weill Cornell Medical College, New York, NY 10065, USA.
  10. 10Molecular Cytology Core Facility, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
  11. 11Molecular Pharmacology and Chemistry Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
  12. 12Radiochemistry and Imaging Sciences Service, Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
  13. 13Department of Pathology, University Medical Center Utrecht, Utrecht, Netherlands.
  14. 14Department of Urology, Weill Cornell Medical College, New York, NY 10065, USA.
  15. 15Department of Medical Radiation Physics, Lund University, Lund, Sweden.
  16. 16Departments of Biology and Biomedical and Translational Sciences, Rowan University, Glassboro, NJ 08028, USA.
  17. 17Genitourinary Oncology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
  18. 18Department of Medicine, Weill Cornell Medical College, New York, NY 10065, USA.
  19. 19Department of Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
  20. 20Nuffield Department of Surgical Sciences, University of Oxford, Oxford, U.K.
  21. 21Department of Laboratory Medicine, Lund University, Malmö, Sweden.
  22. 22Division of Urological Research, Department of Clinical Sciences, Lund University, Malmö, Sweden.
  1. Corresponding author. Email: ulmerth{at}mskcc.org (D.U.); liljah{at}mskcc.org (H.L.); larsons{at}mskcc.org (S.M.L.)
    • * These authors contributed equally to this work.

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