Research ArticleCancer

Internalization of secreted antigen–targeted antibodies by the neonatal Fc receptor for precision imaging of the androgen receptor axis

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Science Translational Medicine  30 Nov 2016:
Vol. 8, Issue 367, pp. 367ra167
DOI: 10.1126/scitranslmed.aaf2335

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Prostate cancer hide-and-seek

Prostate cancer is typically treated by targeting the androgen receptor, at least initially, but there is no convenient way to monitor the receptor’s activity or to determine when a tumor is becoming resistant to treatment. Although the androgen receptor cannot be imaged directly at this time, Thorek et al. identified an enzyme called human kallikrein-related peptidase 2 (hK2), whose activation requires signaling through the androgen receptor pathway. The authors used a radiolabeled antibody against hK2 in mouse models and human tissues to accurately detect prostate cancer lesions, including bone metastases, and to monitor their status during the course of treatment.