Contents
30 November 2016
Vol 8, Issue 367
Vol 8, Issue 367
Contents
Research Articles
- Improved cancer immunotherapy by a CD25-mimobody conferring selectivity to human interleukin-2
An antibody to human IL-2 phenocopies CD25 and improves IL-2–based cancer immunotherapy.
- Internalization of secreted antigen–targeted antibodies by the neonatal Fc receptor for precision imaging of the androgen receptor axis
A radiolabeled antibody against a secreted antigen uses Fc receptor–mediated internalization for cancer imaging and therapy.
- Oral thrombin inhibitor aggravates platelet adhesion and aggregation during arterial thrombosis
Blood treated with an oral thrombin inhibitor demonstrates enhanced thrombus formation under flow conditions in humans and in rodents.
- Imaging mitochondrial dynamics in human skin reveals depth-dependent hypoxia and malignant potential for diagnosis
In vivo, label-free evaluation of mitochondrial function in human skin epithelia noninvasively differentiates healthy from cancerous tissues.
- Nigral dopaminergic PAK4 prevents neurodegeneration in rat models of Parkinson’s disease
PAK4-CRTC1 signaling in dopaminergic neurons mediates neuroprotection in rodent models of Parkinson’s disease.
Editors' Choice
- Taking cancer drug screening very personally
Liposomal nanoformulations and DNA barcodes reveal therapeutic potencies of anticancer drugs directly in tumors.
- Imaging serotonin reuptake in the living brain
A new molecular fMRI method allows for investigation of serotonin dynamics in the living brain.
- Grave effects of a specific immune therapy
Antigen-specific immune therapy unexpectedly worsens Graves’ disease in a spontaneous animal model.
- Muscling out gene mutations
An adenovirus system that delivers gene-editing components rescues dystrophin expression in Duchenne muscular dystrophy muscle cells.
About The Cover
ONLINE COVER Revealing Mitochondria. Shown are human skin cells in which mitochondria are fused and extend throughout the cytoplasm. Cells are stained with TMRE; the red color indicates maximally polarized mitochondria. In this issue, Pouli et al. report that skin cancer cells can be detected in vivo by visualizing dynamic changes in the structure and function of mitochondria, as revealed by the endogenous fluorescence of the metabolic cofactor NADH. [CREDIT: DIMITRA POULI/BIOMEDICAL ENGINEERING DEPARTMENT, TUFTS UNIVERSITY]