Research ArticleGENETIC DISORDERS

Two tissue-resident progenitor lineages drive distinct phenotypes of heterotopic ossification

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Science Translational Medicine  23 Nov 2016:
Vol. 8, Issue 366, pp. 366ra163
DOI: 10.1126/scitranslmed.aaf1090

Article Information

vol. 8 no. 366 366ra163

PubMed: 
Print ISSN: 
Online ISSN: 
History: 
  • Received for publication April 28, 2015
  • Accepted for publication September 23, 2016

Author Information

  1. Devaveena Dey1,
  2. Jana Bagarova1,
  3. Sarah J. Hatsell2,
  4. Kelli A. Armstrong1,
  5. Lily Huang2,
  6. Joerg Ermann3,
  7. Ashley J. Vonner1,
  8. Yue Shen1,
  9. Agustin H. Mohedas1,
  10. Arthur Lee4,
  11. Elisabeth M. W. Eekhoff5,
  12. Annelies van Schie5,
  13. Marie B. Demay6,
  14. Charles Keller7,
  15. Amy J. Wagers8,9,
  16. Aris N. Economides2,10 and
  17. Paul B. Yu1,*
  1. 1Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA.
  2. 2Regeneron Pharmaceuticals Inc., 777 Old Saw Mill River Road, Tarrytown, NY 10591, USA.
  3. 3Division of Rheumatology, Immunology, and Allergy, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA.
  4. 4National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD 20850, USA.
  5. 5Departments of Internal Medicine, Endocrine Section, and Epidemiology and Biostatistics, VU University Medical Center, PO Box 7057, Amsterdam 1007 MB, Netherlands.
  6. 6Endocrine Unit, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Boston, MA 02114, USA.
  7. 7Children’s Cancer Therapy Development Institute, 12655 SW Beaverdam Road-West, Beaverton, OR 97005, USA.
  8. 8Department of Stem Cell and Regenerative Biology, Harvard University and Harvard Stem Cell Institute, Cambridge, MA 02138, USA.
  9. 9Joslin Diabetes Center, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.
  10. 10Regeneron Genetics Center, Tarrytown, NY 10591, USA.
  1. *Corresponding author. Email: pbyu{at}partners.org

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