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Nanobodies that block gating of the P2X7 ion channel ameliorate inflammation

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Science Translational Medicine  23 Nov 2016:
Vol. 8, Issue 366, pp. 366ra162
DOI: 10.1126/scitranslmed.aaf8463

Article Information

vol. 8 no. 366 366ra162

PubMed: 
Print ISSN: 
Online ISSN: 
History: 
  • Received for publication August 18, 2015
  • Resubmitted April 11, 2016
  • Accepted for publication October 27, 2016
  • .

Author Information

  1. Welbeck Danquah1,*,,
  2. Catherine Meyer-Schwesinger2,*,
  3. Björn Rissiek1,3,*,
  4. Carolina Pinto1,
  5. Arnau Serracant-Prat1,
  6. Miriam Amadi1,
  7. Domenica Iacenda1,3,
  8. Jan-Hendrik Knop1,2,
  9. Anna Hammel1,2,
  10. Philine Bergmann1,4,
  11. Nicole Schwarz1,
  12. Joana Assunção5,,
  13. Wendy Rotthier5,
  14. Friedrich Haag1,
  15. Eva Tolosa1,
  16. Peter Bannas1,6,
  17. Eric Boué-Grabot4,
  18. Tim Magnus3,
  19. Toon Laeremans5,§,
  20. Catelijne Stortelers5 and
  21. Friedrich Koch-Nolte1,
  1. 1Institute of Immunology, University Medical Center Hamburg-Eppendorf, Martinistraße 52, D-20246 Hamburg, Germany.
  2. 2Department of Nephrology, University Medical Center Hamburg-Eppendorf, Martinistraße 52, D-20246 Hamburg, Germany.
  3. 3Department of Neurology, University Medical Center Hamburg-Eppendorf, Martinistraße 52, D-20246 Hamburg, Germany.
  4. 4Université de Bordeaux, Institut des Maladies Neurodégénératives, CNRS UMR 5293, Bordeaux 33076, France.
  5. 5Ablynx NV, Technologiepark 21, B-9052 Zwijnaarde, Belgium.
  6. 6Department of Radiology, University Medical Center Hamburg-Eppendorf, Martinistraße 52, D-20246 Hamburg, Germany.
  1. ||Corresponding author. Email: nolte{at}uke.de
    • * These authors contributed equally to this work.

    • Present address: Evotec AG, Essener Bogen 7, 22419 Hamburg, Germany.

    • Present address: FairJourney Biologics, Rua do Campo Alegre 1021, 4169-007 Porto, Portugal.

    • § Present address: Confo Therapeutics, Pleinlaan 2, 1050 Brussels, Belgium.

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