Research ArticleCancer

Lowered H3K27me3 and DNA hypomethylation define poorly prognostic pediatric posterior fossa ependymomas

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Science Translational Medicine  23 Nov 2016:
Vol. 8, Issue 366, pp. 366ra161
DOI: 10.1126/scitranslmed.aah6904

Article Information

vol. 8 no. 366 366ra161

PubMed: 
Print ISSN: 
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History: 
  • Received for publication December 17, 2015
  • Resubmitted August 2, 2016
  • Accepted for publication October 19, 2016
  • .

Author Information

  1. Jill Bayliss1,*,
  2. Piali Mukherjee2,*,
  3. Chao Lu3,*,
  4. Siddhant U. Jain4,
  5. Chan Chung1,
  6. Daniel Martinez5,
  7. Benjamin Sabari3,
  8. Ashley S. Margol6,
  9. Pooja Panwalkar1,
  10. Abhijit Parolia1,7,
  11. Melike Pekmezci8,
  12. Richard C. McEachin9,
  13. Marcin Cieslik1,7,
  14. Benita Tamrazi10,
  15. Benjamin A. Garcia11,
  16. Gaspare La Rocca12,
  17. Mariarita Santi5,
  18. Peter W. Lewis4,
  19. Cynthia Hawkins13,14,
  20. Ari Melnick2,
  21. C. David Allis3,
  22. Craig B. Thompson12,
  23. Arul M. Chinnaiyan1,7,
  24. Alexander R. Judkins15, and
  25. Sriram Venneti1,
  1. 1Department of Pathology, University of Michigan, Ann Arbor, MI 48104, USA.
  2. 2Epigenomics Core Facility, Weill Medical College of Cornell University, New York, NY 10065, USA.
  3. 3Laboratory of Chromatin Biology and Epigenetics, Rockefeller University, New York, NY 10065, USA.
  4. 4Department of Biomolecular Chemistry, School of Medicine and Public Health, University of Wisconsin, Madison, WI 53715, USA.
  5. 5Department of Pathology, Children’s Hospital of Philadelphia, University of Pennsylvania, Philadelphia, PA 19104, USA.
  6. 6Department of Pediatrics, Children’s Hospital Los Angeles, Keck School of Medicine, University of Southern California, Los Angeles, CA 90027, USA.
  7. 7Michigan Center for Translational Pathology, Howard Hughes Medical Institute, University of Michigan, Ann Arbor, MI 48104, USA.
  8. 8Department of Pathology, University of California, San Francisco, San Francisco, CA 94143, USA.
  9. 9Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 48104, USA.
  10. 10Department of Radiology, Children’s Hospital Los Angeles, Keck School of Medicine, University of Southern California, Los Angeles, CA 90027, USA.
  11. 11Epigenetics Program, Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
  12. 12Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
  13. 13Arthur and Sonia Labatt Brain Tumour Research Centre and Division of Pathology, The Hospital for Sick Children, Toronto, Ontario, Canada.
  14. 14Faculty of Medicine, Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada.
  15. 15Department of Pathology and Laboratory Medicine, Children’s Hospital Los Angeles, Keck School of Medicine, University of Southern California, Los Angeles, CA 90027, USA.
  1. Corresponding author. Email: ajudkins{at}chla.usc.edu (A.R.J.); svenneti{at}med.umich.edu (S.V.)
    • * These authors contributed equally to this work.

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