Contents
23 November 2016
Vol 8, Issue 366
Vol 8, Issue 366
Contents
Editorial
- NIH’s transformative opportunities for the behavioral and social sciences
NIH OBSSR’s new strategic plan is designed to speed up research and translation in the behavioral and social sciences.
Research Articles
- Lowered H3K27me3 and DNA hypomethylation define poorly prognostic pediatric posterior fossa ependymomas
A subset of childhood posterior fossa ependymomas with poor prognosis is epigenetically similar to H3K27M gliomas.
- Nanobodies that block gating of the P2X7 ion channel ameliorate inflammation
Single-domain antibodies called nanobodies block P2X7, an inflammatory ion channel, reducing skin and kidney inflammation in mice.
- Two tissue-resident progenitor lineages drive distinct phenotypes of heterotopic ossification
Tissue-specific manifestations of the congenital bone-forming syndrome FOP are mediated by multiple tissue-resident stem cell populations.
- Effects of a gut pathobiont in a gnotobiotic mouse model of childhood undernutrition
Pathobiont-associated cachexia in a gnotobiotic model of childhood undernutrition is determined by strain-level interactions within the gut microbiota.
- A soft, wearable microfluidic device for the capture, storage, and colorimetric sensing of sweat
A soft, skin-mounted microfluidic device captures microliter volumes of sweat and quantitatively measures biochemical markers by colorimetric analysis.
Editors' Choice
- Photoacoustic imaging sounds the alarm on liver fibrosis
A handheld photoacoustic and ultrasound imaging system detects liver fibrosis in mice and has the potential to be translated for noninvasive imaging in patients.
- Bugs clogging your arteries? Take an anti-B2 shot
Commensal microbiota promote atherosclerosis by activating immune cells.
- Sweet signals and diabetes: Carbohydrate-binding proteins contribute to insulin resistance
A macrophage-secreted lectin, galectin-3, may contribute to insulin resistance in obesity.
- Biomaterials-based biologic burst release builds better bone
Localized pulsatile delivery of pro-bone forming parathyroid hormone from biomaterials results in enhanced bone regeneration.
About The Cover
ONLINE COVER Sensing Sweat's Secrets. A flexible microfluidic device developed by Koh et al. adheres to human skin and captures and analyzes sweat as individuals exercise. The snaky outer channel (blue) indicates sweat rate and volume, and the four inner circles change color in response to chloride, glucose, lactate, and pH in sweat. Using smartphone image capture to analyze color changes, Koh et al. obtained results—from bicyclists wearing the microfluidic device during indoor testing—that were similar to results obtained with standard sweat analysis. This noninvasive biosensor could help prevent overtraining and dehydration during exercise or could be adapted to analyze saliva, tears, or other biofluids. [CREDIT: KOH ET AL./SCIENCE TRANSLATIONAL MEDICINE]