Research ArticleCardiovascular Disease

Reloadable multidrug capturing delivery system for targeted ischemic disease treatment

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Science Translational Medicine  16 Nov 2016:
Vol. 8, Issue 365, pp. 365ra160
DOI: 10.1126/scitranslmed.aah6228

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Restoring functional tissue after ischemia is thought to require neovascularization to replace the occluded blood vessels. Neovascularization can be induced by growth factor proteins, but they generally have short half-lives in circulation and are difficult to deliver to the site of injury. Wu et al. have designed a reloadable system that uses antibodies embedded in a hydrogel to capture tagged growth factor therapeutics and retain them at the site of ischemic injury. Moreover, it can be easily reloaded by intravenous injection of additional growth factors doses, which are then captured by the antibody-based system. The authors demonstrated the efficacy and safety of this system in mouse and pig models of limb ischemia, suggesting a potential for future clinical development.

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