Research ArticleBIOMATERIALS

An injectable shear-thinning biomaterial for endovascular embolization

See allHide authors and affiliations

Science Translational Medicine  16 Nov 2016:
Vol. 8, Issue 365, pp. 365ra156
DOI: 10.1126/scitranslmed.aah5533

You are currently viewing the editor's summary.

View Full Text

Log in to view the full text

Log in through your institution

Log in through your institution

Stopping blood in its tracks

Effective treatments for ruptured blood vessels must be rapidly deployed to promote hemostasis. Avery et al. formulated a gelatin and silicate nanoplatelet hydrogel material that occluded blood flow without requiring thrombus formation. When injected into arteries and veins in mice and pigs, the biomaterial occluded blood flow without evidence of fragmentation or displacement for up to 24 days. Occluded vessels showed evidence of connective tissue replacing the biomaterial in the vessel lumen. Shear-thinning biomaterials represent promising alternatives for stable endovascular embolization.