16 November 2016
Vol 8, Issue 365
  • Contents

    • Research Articles

      • Oral, ultra–long-lasting drug delivery: Application toward malaria elimination goals

        A newly developed platform capable of oral, ultra–long-acting drug delivery could be applied against the malaria vector in elimination programs.

      • Elucidating the interplay between IgG-Fc valency and FcγR activation for the design of immune complex inhibitors

        An engineered trivalent Fc drug candidate is a potent inhibitor of FcγR-driven immune cell activation and autoimmune diseases in animal models.

      • The synthetic diazonamide DZ-2384 has distinct effects on microtubule curvature and dynamics without neurotoxicity

        A compound that binds to tubulin in an unusual way has superior antitumor efficacy and safety and has a distinctive impact on microtubule curvature and dynamics.

    • Editors' Choice

      • Synthetic lethality and beyond

        DNA damage–induced binding of DNA methyltransferases maximizes the efficacy of poly(ADP-ribose) polymerase inhibitors.

      • Boosting dopamine to lift depression?

        The brain reward circuit that is dysfunctional in depression can be targeted pharmacologically.

      • The lung’s defensive line

        Resident memory T cells in human airway tissues encode specialized programs for retention, maintenance, and rapid but controlled effector function.

      • Size no longer matters

        A method for genome-wide profiling of small RNAs, such as microRNAs, from single cells is developed and applied to human cancer and stem cells.

About The Cover

Cover image expansion

ONLINE COVER Stemming Blood Loss Without Thrombosis. This image shows a catheter deploying a biomaterial to occlude a leaking blood vessel. A shear-thinning biomaterial formulated by Avery et al. produced a plug that effectively halted blood flow without relying on the formation of blood clots. The biomaterial was delivered into mouse and pig blood vessels and formed a stable plug that stemmed blood flow. The shear thinning biomaterial could be applied to halt blood loss in scenarios where blood clotting is compromised. [CREDIT: S. MASOUD MOOSAVI-BASRI/SHARIF UNIVERSITY OF TECHNOLOGY]