Research ArticleHuman Genetics

Aggregate penetrance of genomic variants for actionable disorders in European and African Americans

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Science Translational Medicine  09 Nov 2016:
Vol. 8, Issue 364, pp. 364ra151
DOI: 10.1126/scitranslmed.aag2367

Article Information

vol. 8 no. 364 364ra151

PubMed: 
Print ISSN: 
Online ISSN: 
History: 
  • Received for publication June 23, 2016
  • Accepted for publication September 30, 2016

Author Information

  1. Pradeep Natarajan1,2,3,*,
  2. Nina B. Gold2,4,*,
  3. Alexander G. Bick2,3,5,*,
  4. Heather McLaughlin2,6,7,
  5. Peter Kraft8,
  6. Heidi L. Rehm2,6,7,
  7. Gina M. Peloso2,3,
  8. James G. Wilson9,
  9. Adolfo Correa10,
  10. Jonathan G. Seidman2,5,
  11. Christine E. Seidman2,5,11,12,
  12. Sekar Kathiresan1,2,3, and
  13. Robert C. Green2,3,7,11,,
  1. 1Center for Human Genetic Research, Cardiovascular Research Center, and Cardiology Division, Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA.
  2. 2Harvard Medical School, Boston, MA 02115, USA.
  3. 3Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, MA 02142, USA.
  4. 4Boston Children’s Hospital, Boston, MA 02115, USA.
  5. 5Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.
  6. 6Department of Pathology, Brigham and Women’s Hospital, Boston, MA 02115, USA.
  7. 7Partners HealthCare Personalized Medicine, Boston, MA 02115, USA.
  8. 8Departments of Epidemiology and Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.
  9. 9Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS 39216, USA.
  10. 10Departments of Pediatrics and Medicine, University of Mississippi Medical Center, Jackson, MS 39216, USA.
  11. 11Department of Medicine, Brigham and Women’s Hospital, Boston, MA 02115, USA.
  12. 12Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115, USA.
  1. Corresponding author. Email: rcgreen{at}bwh.harvard.edu
    • * These authors contributed equally to this work.

    • These authors contributed equally to this work.

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