Contents
09 November 2016
Vol 8, Issue 364
Vol 8, Issue 364
Contents
Perspective
- Neurodegeneration: From cellular concepts to clinical applications
Developing therapies for neurodegenerative diseases will require new scientific approaches.
Research Articles
- Aggregate penetrance of genomic variants for actionable disorders in European and African Americans
In two separate analyses, people with disease-associated mutations exhibited features of the corresponding disease more often than expected, a result that supports the use of population-based genetic screening.
- Imaging matrix metalloproteinase activity in multiple sclerosis as a specific marker of leukocyte penetration of the blood-brain barrier
A method to visualize MMPs reveals penetration of the blood-brain barrier by leukocytes early in multiple sclerosis.
- Local and transient gene expression primes the liver to resist cancer metastasis
Targeted nanoparticles induce expression of a CXCL12/SDF-1 trap in a transient and liver-specific manner to inhibit colorectal cancer liver metastasis.
- Calciprotein particles as potential etiologic agents of idiopathic preterm birth
Aggregation of calciprotein particles in amniotic fluid may play a pathogenic role in idiopathic preterm birth.
- Distinct biological subtypes and patterns of genome evolution in lymphoma revealed by circulating tumor DNA
Circulating tumor DNA reveals patterns of clonal evolution and allows classification of tumor subtypes in lymphoma.
Editors' Choice
- Macrophages build a wall and the host pays for it
Epithelioid-like macrophages suppress immunity during mycobacterial infection.
- On antidepressants and still feeling low
Early-life stress and amygdala reactivity predict the therapeutic effect of antidepressants.
- T regulating lymphedema
Adoptive T regulatory cell therapy lessens disease severity in a surgical mouse tail lymphedema model.
About The Cover
ONLINE COVER A New View of Multiple Sclerosis. Brain image of a patient with multiple sclerosis resulting from superposition of (MRI) and (PET) with a probe targeting matrix metalloproteinases. This new imaging method reveals early leukocyte infiltration of the brain in patients with multiple sclerosis and resolution of this pathogenic event in response to treatment (Gerwien et al.) [CREDIT: GERWIEN ET AL./SCIENCE TRANSLATIONAL MEDICINE]