Research ArticleAlzheimer’s Disease

The BACE1 inhibitor verubecestat (MK-8931) reduces CNS β-amyloid in animal models and in Alzheimer’s disease patients

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Science Translational Medicine  02 Nov 2016:
Vol. 8, Issue 363, pp. 363ra150
DOI: 10.1126/scitranslmed.aad9704

Article Information

vol. 8 no. 363 363ra150

PubMed: 
Print ISSN: 
Online ISSN: 
History: 
  • Received for publication March 1, 2016
  • Accepted for publication October 14, 2016
  • .

Author Information

  1. Matthew E. Kennedy1,*,
  2. Andrew W. Stamford2,*,
  3. Xia Chen1,
  4. Kathleen Cox3,
  5. Jared N. Cumming2,
  6. Marissa F. Dockendorf3,
  7. Michael Egan4,
  8. Larry Ereshefsky5,
  9. Robert A. Hodgson1,,
  10. Lynn A. Hyde1,
  11. Stanford Jhee5,
  12. Huub J. Kleijn3,,
  13. Reshma Kuvelkar1,
  14. Wei Li2,
  15. Britta A. Mattson6,
  16. Hong Mei3,
  17. John Palcza7,
  18. Jack D. Scott2,
  19. Michael Tanen8,
  20. Matthew D. Troyer9,§,
  21. Jack L. Tseng9,,
  22. Julie A. Stone3,
  23. Eric M. Parker1,* and
  24. Mark S. Forman9,*
  1. 1Department of Neuroscience, Merck Research Laboratories, Kenilworth, NJ 07033, USA.
  2. 2Department of Global Chemistry, Merck Research Laboratories, Kenilworth, NJ 07033, USA.
  3. 3Department of Pharmacokinetics, Pharmacodynamics and Drug Metabolism, Merck Research Laboratories, Kenilworth, NJ 07033, USA.
  4. 4Department of Clinical Research, Merck Research Laboratories, Kenilworth, NJ 07033, USA.
  5. 5PAREXEL, Glendale, CA 91206, USA.
  6. 6Department of Safety Assessment, Merck Research Laboratories, West Point, PA 19446, USA.
  7. 7Department of Biostatistics, Merck Research Laboratories, Kenilworth, NJ 07033, USA.
  8. 8Translational Biomarkers Department, Merck Research Laboratories, Kenilworth, NJ 07033, USA.
  9. 9Department of Translational Medicine, Merck Research Laboratories, Kenilworth, NJ 07033, USA.
  1. *Corresponding author. Email: matthew.kennedy{at}merck.com (M.E.K.); andy.stamford1{at}gmail.com (A.W.S.); ericmcparker{at}comcast.net (E.M.P.); mark.forman{at}merck.com (M.S.F.)
  • Present address: Charles River Laboratories, Wilmington, MA 01887, USA.

  • Present address: Quantitative Solutions, Oss, Netherlands.

  • § Present address: Medivation, San Francisco, CA 94105, USA.

  • Present address: Purdue Pharma, Stamford, CT 06901, USA.

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