Research ArticleTissue Engineering

Cardiac repair in guinea pigs with human engineered heart tissue from induced pluripotent stem cells

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Science Translational Medicine  02 Nov 2016:
Vol. 8, Issue 363, pp. 363ra148
DOI: 10.1126/scitranslmed.aaf8781

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A patch for a broken heart

A heart attack destroys cardiac muscle, resulting in a fibrotic scar. Weinberger et al. created a living patch for injured hearts using endothelial and cardiac cells grown from human induced pluripotent stem cells. These three-dimensional strips were placed over injured areas of guinea pig hearts; 28 days later, the injured area was partly remuscularized, and the heart pumped ~30% better than just after the injury. The grafts also contained new blood vessels and, in some cases, were electrically coupled to the healthy parts of the heart. These human heart patches may one day help patients recover cardiac function after a heart attack.

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