Contents
Vol 8, Issue 363
Contents
Research Articles
- Genetic interrogation of circulating multiple myeloma cells at single-cell resolution
Circulating tumor cells provide a practical and noninvasive way to monitor multiple myeloma.
- Cardiac repair in guinea pigs with human engineered heart tissue from induced pluripotent stem cells
Human engineered heart tissue derived from induced pluripotent stem cells improves cardiac function in guinea pigs.
- Resolving TYK2 locus genotype-to-phenotype differences in autoimmunity
Resolving TYK2 locus genotype-to-phenotype differences reveals an immune signaling optimum that may be exploited therapeutically for treating autoimmune diseases.
- The BACE1 inhibitor verubecestat (MK-8931) reduces CNS β-amyloid in animal models and in Alzheimer’s disease patients
The BACE1 inhibitor verubecestat safely reduces β-amyloid deposition in rats, monkeys, healthy human subjects, and patients with Alzheimer’s disease.
Reports
- Fetal genome profiling at 5 weeks of gestation after noninvasive isolation of trophoblast cells from the endocervical canal
Fetal trophoblast cells obtained noninvasively early in gestation provided fetal DNA for comprehensive targeted sequencing across the genome.
Editors' Choice
- Fat weighing down the insulin receptor
Threonine phosphorylation of the insulin receptor promotes diabetes.
- An apple a day may not keep the doctor away, if you have AML
When glucose demand outstrips supply, AML cells use fructose for fuel instead, as a metabolic adaptation that could represent a therapeutic vulnerability.
- Stronger together
Improved endothelial progenitor cell proliferation function supports hematopoietic stem cell proliferation after allogeneic stem cell transplant engraftment.
- Caspase-2: Divide and conquer
Preventing caspase-2 cleavage of tau blocks memory impairment in an animal model of Alzheimer’s disease.
- Sleepy, leaky gut
Chronic sleep disruption leads to alteration of gut microbiota, systemic and adipose tissue inflammation, and insulin resistance in mice.
About The Cover

ONLINE COVER A Broken Heart, Mended. Shown is an injured guinea pig heart successfully repaired with a living patch of tissue grown from human stem cells (Weinberger et al.). The patch contained stem cell–derived blood vessel and heart cells, which caused remuscularization of the injured area and improved pumping of the heart. [CREDIT: KAJA BRECKWOLDT, UNIVERSITY MEDICAL CENTER HAMBURG-EPPENDORF]