Contents

Contents

• Research Articles

  • Genetic interrogation of circulating multiple myeloma cells at single-cell resolution

    By Jens G. Lohr, Sora Kim, Joshua Gould, Birgit Knoechel, Yotam Drier, Matthew J. Cotton, Daniel Gray, Nicole Birrer, Bang Wong, Gavin Ha, Cheng-Zhong Zhang, Guangwu Guo, Matthew Meyerson, Andrew J. Yee, Jesse S. Boehm, Noopur Raje, Todd R. Golub

    Science Translational Medicine02 Nov 2016 : 363ra147 Full AccessRestricted Access

    Circulating tumor cells provide a practical and noninvasive way to monitor multiple myeloma.

    • Editor's Summary
    • Abstract
    • Full Text
    • PDF
    • Supplementary Materials

  • Cardiac repair in guinea pigs with human engineered heart tissue from induced pluripotent stem cells

    By Florian Weinberger, Kaja Breckwoldt, Simon Pecha, Allen Kelly, Birgit Geertz, Jutta Starbatty, Timur Yorgan, Kai-Hung Cheng, Katrin Lessmann, Tomas Stolen, Marielle Scherrer-Crosbie, Godfrey Smith, Hermann Reichenspurner, Arne Hansen, Thomas Eschenhagen

    Science Translational Medicine02 Nov 2016 : 363ra148 Full AccessRestricted Access

    Human engineered heart tissue derived from induced pluripotent stem cells improves cardiac function in guinea pigs.

    • Editor's Summary
    • Abstract
    • Full Text
    • PDF
    • Supplementary Materials

  • Resolving TYK2 locus genotype-to-phenotype differences in autoimmunity

    By Calliope A. Dendrou, Adrian Cortes, Lydia Shipman, Hayley G. Evans, Kathrine E. Attfield, Luke Jostins, Thomas Barber, Gurman Kaur, Subita Balaram Kuttikkatte, Oliver A. Leach, Christiane Desel, Soren L. Faergeman, Jane Cheeseman, Matt J. Neville, Stephen Sawcer, Alastair Compston, Adam R. Johnson, Christine Everett, John I. Bell, Fredrik Karpe, Mark Ultsch, Charles Eigenbrot, Gil McVean, Lars Fugger

    Science Translational Medicine02 Nov 2016 : 363ra149 Full AccessRestricted Access

    Resolving TYK2 locus genotype-to-phenotype differences reveals an immune signaling optimum that may be exploited therapeutically for treating autoimmune diseases.

    • Editor's Summary
    • Abstract
    • Full Text
    • PDF
    • Supplementary Materials

  • The BACE1 inhibitor verubecestat (MK-8931) reduces CNS β-amyloid in animal models and in Alzheimer’s disease patients

    By Matthew E. Kennedy, Andrew W. Stamford, Xia Chen, Kathleen Cox, Jared N. Cumming, Marissa F. Dockendorf, Michael Egan, Larry Ereshefsky, Robert A. Hodgson, Lynn A. Hyde, Stanford Jhee, Huub J. Kleijn, Reshma Kuvelkar, Wei Li, Britta A. Mattson, Hong Mei, John Palcza, Jack D. Scott, Michael Tanen, Matthew D. Troyer, Jack L. Tseng, Julie A. Stone, Eric M. Parker, Mark S. Forman

    Science Translational Medicine02 Nov 2016 : 363ra150 Full AccessRestricted Access

    The BACE1 inhibitor verubecestat safely reduces β-amyloid deposition in rats, monkeys, healthy human subjects, and patients with Alzheimer’s disease.

    • Editor's Summary
    • Abstract
    • Full Text
    • PDF
    • Supplementary Materials

• Reports

  • Fetal genome profiling at 5 weeks of gestation after noninvasive isolation of trophoblast cells from the endocervical canal

    By Chandni V. Jain, Leena Kadam, Marie van Dijk, Hamid-Reza Kohan-Ghadr, Brian A. Kilburn, Craig Hartman, Vicki Mazzorana, Allerdien Visser, Michael Hertz, Alan D. Bolnick, Rani Fritz, D. Randall Armant, Sascha Drewlo

    Science Translational Medicine02 Nov 2016 : 363re4 Full AccessRestricted Access

    Fetal trophoblast cells obtained noninvasively early in gestation provided fetal DNA for comprehensive targeted sequencing across the genome.

    • Editor's Summary
    • Abstract
    • Full Text
    • PDF
    • Supplementary Materials

• Editors' Choice

  • Fat weighing down the insulin receptor

    By J. Mark Brown

    Science Translational Medicine02 Nov 2016 : 363ec173 Full AccessRestricted Access

    Threonine phosphorylation of the insulin receptor promotes diabetes.

    • Full Text

  • An apple a day may not keep the doctor away, if you have AML

    By Saar Gill

    Science Translational Medicine02 Nov 2016 : 363ec174 Full AccessRestricted Access

    When glucose demand outstrips supply, AML cells use fructose for fuel instead, as a metabolic adaptation that could represent a therapeutic vulnerability.

    • Full Text

  • Stronger together

    By Monica L. Hulbert

    Science Translational Medicine02 Nov 2016 : 363ec175 Full AccessRestricted Access

    Improved endothelial progenitor cell proliferation function supports hematopoietic stem cell proliferation after allogeneic stem cell transplant engraftment.

    • Full Text

  • Caspase-2: Divide and conquer

    By Ian Martin

    Science Translational Medicine02 Nov 2016 : 363ec176 Full AccessRestricted Access

    Preventing caspase-2 cleavage of tau blocks memory impairment in an animal model of Alzheimer’s disease.

    • Full Text

  • Sleepy, leaky gut

    By Brendan P. Lucey

    Science Translational Medicine02 Nov 2016 : 363ec177 Full AccessRestricted Access

    Chronic sleep disruption leads to alteration of gut microbiota, systemic and adipose tissue inflammation, and insulin resistance in mice.

    • Full Text