Melanocortin-1 receptor activation is neuroprotective in mouse models of neuroinflammatory disease

Nadine Mykicki; Alexander M. Herrmann; Nicholas Schwab; René Deenen; Tim Sparwasser; Andreas Limmer; Lydia Wachsmuth; Luisa Klotz; Karl Köhrer; Cornelius Faber; Heinz Wiendl; Thomas A. Luger; Sven G. Meuth; Karin Loser

doi:10.1126/scitranslmed.aaf8732

Research ArticleMultiple Sclerosis

Melanocortin-1 receptor activation is neuroprotective in mouse models of neuroinflammatory disease

Nadine Mykicki¹,²,
Alexander M. Herrmann²,³,
Nicholas Schwab³,
René Deenen⁴,
Tim Sparwasser⁵,
Andreas Limmer⁶,
Lydia Wachsmuth⁷,
Luisa Klotz³,
Karl Köhrer⁴,
Cornelius Faber²,⁷,⁸,
Heinz Wiendl²,³,⁸,
Thomas A. Luger¹,²,
Sven G. Meuth²,³,⁸,* and
Karin Loser¹,²,⁸,*,†

¹Department of Dermatology, University of Münster, 48149 Münster, Germany.
²Cells in Motion—Cluster of Excellence, University of Münster, 48149 Münster, Germany.
³Department of Neurology, University of Münster, 48149 Münster, Germany.
⁴Biological and Medical Research Center, University of Düsseldorf, 40225 Düsseldorf, Germany.
⁵Institute of Infection Immunology, TWINCORE Centre for Experimental and Clinical Infection Research, 30625 Hannover, Germany.
⁶Clinic for Orthopedic and Trauma Surgery, University Clinic of Bonn, 53127 Bonn, Germany.
⁷Department of Clinical Radiology, University of Münster, 48149 Münster, Germany.
⁸CRC1009 Breaking Barriers and CRC-TR 128 Multiple Sclerosis, University of Münster, 48149 Münster, Germany.

↵†Corresponding author. Email: loserk{at}uni-muenster.de

↵* These authors contributed equally to this work.

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Science Translational Medicine 26 Oct 2016:
Vol. 8, Issue 362, pp. 362ra146
DOI: 10.1126/scitranslmed.aaf8732

Nadine Mykicki

Department of Dermatology, University of Münster, 48149 Münster, Germany.

Cells in Motion—Cluster of Excellence, University of Münster, 48149 Münster, Germany.

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Alexander M. Herrmann

Cells in Motion—Cluster of Excellence, University of Münster, 48149 Münster, Germany.

Department of Neurology, University of Münster, 48149 Münster, Germany.

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Nicholas Schwab

Department of Neurology, University of Münster, 48149 Münster, Germany.

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René Deenen

Biological and Medical Research Center, University of Düsseldorf, 40225 Düsseldorf, Germany.

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Tim Sparwasser

Institute of Infection Immunology, TWINCORE Centre for Experimental and Clinical Infection Research, 30625 Hannover, Germany.

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Andreas Limmer

Clinic for Orthopedic and Trauma Surgery, University Clinic of Bonn, 53127 Bonn, Germany.

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Lydia Wachsmuth

Department of Clinical Radiology, University of Münster, 48149 Münster, Germany.

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Luisa Klotz

Department of Neurology, University of Münster, 48149 Münster, Germany.

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Karl Köhrer

Biological and Medical Research Center, University of Düsseldorf, 40225 Düsseldorf, Germany.

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Cornelius Faber

Cells in Motion—Cluster of Excellence, University of Münster, 48149 Münster, Germany.

Department of Clinical Radiology, University of Münster, 48149 Münster, Germany.

CRC1009 Breaking Barriers and CRC-TR 128 Multiple Sclerosis, University of Münster, 48149 Münster, Germany.

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Heinz Wiendl

Cells in Motion—Cluster of Excellence, University of Münster, 48149 Münster, Germany.

Department of Neurology, University of Münster, 48149 Münster, Germany.

CRC1009 Breaking Barriers and CRC-TR 128 Multiple Sclerosis, University of Münster, 48149 Münster, Germany.

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Thomas A. Luger

Department of Dermatology, University of Münster, 48149 Münster, Germany.

Cells in Motion—Cluster of Excellence, University of Münster, 48149 Münster, Germany.

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Sven G. Meuth

Cells in Motion—Cluster of Excellence, University of Münster, 48149 Münster, Germany.

Department of Neurology, University of Münster, 48149 Münster, Germany.

CRC1009 Breaking Barriers and CRC-TR 128 Multiple Sclerosis, University of Münster, 48149 Münster, Germany.

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Karin Loser

Department of Dermatology, University of Münster, 48149 Münster, Germany.

Cells in Motion—Cluster of Excellence, University of Münster, 48149 Münster, Germany.

CRC1009 Breaking Barriers and CRC-TR 128 Multiple Sclerosis, University of Münster, 48149 Münster, Germany.

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For correspondence: loserk@uni-muenster.de

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Melanocortin-1 receptor activation is neuroprotective in mouse models of neuroinflammatory disease

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